FITC标记的丝氨酸/苏氨酸蛋白激酶DCAMKL1抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的丝氨酸/苏氨酸蛋白激酶DCAMKL1抗体
英文名称: Anti-DCAMKL1/FITC
抗体货号: HZ-11455R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 10:22:00
详细资料:  实验方法技术资料
浏览人数:8
诚信指数:754点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-DCAMKL1/FITC Conjugated antibody

FITC标记的丝氨酸/苏氨酸蛋白激酶DCAMKL1抗体

 

产品编号 bs-11455R-FITC
英文名称 Anti-DCAMKL1/FITC
中文名称 FITC标记的丝氨酸/苏氨酸蛋白激酶DCAMKL1抗体
别    名 Calcium/calmodulin-dependent protein kinase type I-like CPG16; Cpg16; Dcl; Dclk; Dclk1; DCLK1_HUMAN; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; KIAA0369; Serine/threonine-protein kinase DCAMKL1; Serine/threonine-protein kinase DCLK1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DCAMKL1 (151-250aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
产品介绍 background:
Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to ?subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortin-like and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.

Function:
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Tissue Specificity:
In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
CaMK subfamily.
Contains 2 doublecortin domains.
Contains 1 protein kinase domain.

Database links:
Entrez Gene: 9201 Human
Entrez Gene: 13175 Mouse
Entrez Gene: 83825 Rat
Omim: 604742 Human
SwissProt: O15075 Human
SwissProt: Q9JLM8 Mouse
SwissProt: O08875 Rat
Unigene: 507755 Human
Unigene: 393242 Mouse
Unigene: 472264 Mouse
Unigene: 155540 Rat
Unigene: 80575 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

Lissencephaly(平滑脑)是一种以不完全的神经元迁移和平滑的脑表面为特征的脑发育异常,表现为严重的智力低下。遗传分析已经确定了两种蛋白质在某些情况下突变,即脑瘤1型蛋白(LIS1)和双BeleCurTin。LIS1显示序列同源性?异三聚体G蛋白的亚基和双BeleCurTin含有一致的ABL***酸化位点。此外,DCAMKL1(双BeleCurt-样和CaM激酶样1)蛋白与双***酸钙同源性。所有三种蛋白在发育中的脑中高度表达,并共同作用以调节涉及神经元迁移的微管。DCAMKL1蛋白编码能够***酸化髓鞘碱性蛋白及其自身的功能性激酶,但其激酶活性似乎不影响其微管聚合活性。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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