FITC标记的肌动蛋白结合蛋白DOC6抗体上海沪震实业有限公司

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产品名称: FITC标记的肌动蛋白结合蛋白DOC6抗体
英文名称: Anti-Advillin/FITC
抗体货号: HZ-11451R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/27 15:26:00
详细资料:  实验方法技术资料
浏览人数:12
诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Advillin/FITC Conjugated antibody 

FITC标记的肌动蛋白结合蛋白DOC6抗体

 

产品编号 bs-11451R-FITC
英文名称 Anti-Advillin/FITC
中文名称 FITC标记的肌动蛋白结合蛋白DOC6抗体
别    名 Actin binding protein DOC 6; Actin binding protein DOC6; Advil; Advillin; AVIL; AVIL_HUMAN; DOC 6; DOC6; p92.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 90kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Advillin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Advillin is an 819 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one HP domain and six gelsolin-like repeats. Expressed at high levels in colon and small intestine and at lower levels in uterus, thymus, testis and prostate, advillin functions as a calcium-regulated Actin-binding protein that may be involved in the development of neuronal cells, specifically those that form ganglia. The gene encoding advillin maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.

Function:
Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis.

Subunit:
Associates (via C-terminus) with actin. Interacts with SCARF1 (By similarity). Interacts with F-actin.

Subcellular Location:
Cytoplasm > cytoskeleton. Cell projection. Cell projection > axon.

Tissue Specificity:
Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus.

Similarity:
Belongs to the villin/gelsolin family.
Contains 6 gelsolin-like repeats.
Contains 1 HP (headpiece) domain.

Database links:

Entrez Gene: 10677 Human

Entrez Gene: 11567 Mouse

Entrez Gene: 79253 Rat

Omim: 613397 Human

SwissProt: O75366 Human

SwissProt: O88398 Mouse

SwissProt: Q9WU06 Rat

Unigene: 584854 Human

Unigene: 10739 Mouse

Unigene: 20161 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

Advestin是一种819个氨基酸的蛋白质,定位于细胞质和细胞骨架,并含有一个Hp结构域和六个凝溶胶蛋白样重复序列。在结肠和小肠的高水平表达,在子宫、胸腺、睾丸和前列腺的较低水平,ADVILN作为钙调节的肌动蛋白结合蛋白发挥作用,可能参与神经细胞的发育,特别是形成神经节的细胞。编码人胰岛素的基因编码到人类12号染色体上,编码1100个以上的基因,约占人类基因组的4.5%。12号染色体与多种疾病和疼痛有关,包括软骨发育不良、软骨发育不全、最不典型增生、努南综合征和12P三体,这会导致面部发育缺陷和癫痫发作。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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