FITC标记的肌动蛋白结合蛋白1抗体上海沪震实业有限公司

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产品名称: FITC标记的肌动蛋白结合蛋白1抗体
英文名称: Anti-ABLIM1/FITC
抗体货号: HZ-11449R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/14 14:18:00
详细资料:  实验方法技术资料
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诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-ABLIM1/FITC Conjugated antibody

FITC标记的肌动蛋白结合蛋白1抗体

 

产品编号 bs-11449R-FITC
英文名称 Anti-ABLIM1/FITC
中文名称 FITC标记的肌动蛋白结合蛋白1抗体
别    名 ABLIM 1; ABLIM; abLIM-1; ABLIM-L; ABLIM-M; ABLIM-S; ABLIM1; ABLM1_HUMAN; Actin binding double zinc finger protein; Actin binding LIM protein 1; Actin binding LIM protein family member 1; Actin-binding double zinc finger protein; Actin-binding double zinc finger protein; Actin-binding LIM protein 1; Actin-binding LIM protein family member 1; DKFZp781D0148; FLJ14564; KIAA0059; LIM actin binding protein 1; LIMAB 1; LIMAB1; Limatin; RGD1565768; RP11-317F20.1.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  细胞骨架  细胞外基质  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 88kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABLIM1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription.

Function:
May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.

Subunit:
Binds F-actin. Interacts with ABRA.

Subcellular Location:
Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton.

Tissue Specificity:
Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.

Similarity:
Contains 1 HP (headpiece) domain.
Contains 4 LIM zinc-binding domains.

Database links:

Entrez Gene: 3983 Human

Entrez Gene: 226251 Mouse

Entrez Gene: 307989 Rat

Omim: 602330 Human

SwissProt: O14639 Human

SwissProt: Q8K4G5 Mouse

Unigene: 438236 Human

Unigene: 538331 Human

Unigene: 593868 Human

Unigene: 217161 Mouse

Unigene: 446592 Mouse

Unigene: 40404 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

秀丽线虫蛋白UNC-115通过调节生长锥肌动蛋白细胞骨架介导轴突导向,以响应生长锥受体所接收的信号。UNC-115的哺乳动物同源物是肌动蛋白结合的LIM蛋白家族成员1(ABLIM1,也被指定为Limatin)。ABLIM1蛋白具有N-末端结构域,其包含四个双锌指基序,其符合LIM基序一致序列。ABLIM1通过F-肌动蛋白通过类似Dimin样结构域结合,并在视网膜、脑和肌肉组织中表达。有四种已知的ABLIM1亚型。编码AbMIL1的基因映射到与人类肿瘤中的杂合性丢失频繁相关的第10染色体区域,从而识别ABLIM1作为候选肿瘤抑制基因。ABLIM2和ABLIM3在肌肉和神经元组织中表达最高,与F-肌动蛋白结合,并定位在应激纤维上。他们还显示,增强星级(横纹肌激活的Rho信号)依赖激活的血清反应因子(SRF),从而调节转录。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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