FITC标记的隐花色素蛋白2抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的隐花色素蛋白2抗体
英文名称: Anti-CRY2/FITC
抗体货号: HZ-11447R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 10:30:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-CRY2/FITC Conjugated antibody

FITC标记的隐花色素蛋白2抗体

 

产品编号 bs-11447R-FITC
英文名称 Anti-CRY2/FITC
中文名称 FITC标记的隐花色素蛋白2抗体
别    名 cry2; CRY2_HUMAN; cryptochrome 2 (photolyase like); Cryptochrome2; Cryptochrome 2; Cryptochrome-2; FLJ10332; growth inhibiting protein 37; HCRY2; KIAA0658; PHLL2; Photolyase like.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cryptochrome 2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Circadian clocks are biological timepieces that regulate hormonal rhythms, sleep cycles and feeding behaviors. These rhythms are generated in the superchiasmatic nucleus (SCN), a cell-autonomous circadian oscillator located within the brain that is synchronized with the environment by light. A number of transcription factors, including Clock and BMAL1, are molecular components of the SCN that induce the expression of proteins involved in light/dark cycle entrainment, which include Per1 and Per2. Tim, for timeless, generates a negative feedback loop that regulates the activity of Clock by suppressing the expression of Clock target genes. Tim forms heterodimers with Per1 and Per2 that bind Clock and block the activation of Clock-BMAL1 dimers to repress Per gene expression. Additionally, the CRY proteins, which are cryptochrome photoreceptors for the circadian clock, function as light-independent inhibitors of the circadian clock. CRY1 and CRY2 negatively regulate SCN components by associating with the activators Clock-BMAL1, and also with the various feedback inhibitors Per1, Per2 and Tim.

Function:
Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.

Subunit:
Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1 and PER2 C-terminal domains. Interaction with PER2 inhibits its ubiquitination and vice versa. Interacts with NFIL3. Interacts with FBXL3.

Subcellular Location:
Cytoplasm. Nucleus. Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.

Tissue Specificity:
Expressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.

Post-translational modifications:
Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2.
Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complex, leading to its degradation.

Similarity:
Belongs to the DNA photolyase class-1 family.
Contains 1 DNA photolyase domain.

Database links:

Entrez Gene: 1408 Human

Entrez Gene: 12953 Mouse

Omim: 603732 Human

SwissProt: Q49AN0 Human

SwissProt: Q9R194 Mouse

Unigene: 532491 Human

Unigene: 254181 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

昼夜节律钟是调节荷尔蒙节律、睡眠周期和喂养行为的生物钟。这些节律在超交叉核(SCN)中产生,位于大脑内的细胞自主昼夜节律振荡器通过光与环境同步。许多转录因子,包括时钟和BMAL1,是SCN的分子成分,其诱导参与光/暗循环夹带的蛋白质的表达,其中包括Pr1和Pr2。提姆,为永恒,产生一个负反馈回路,通过抑制时钟目标基因的表达来调节时钟的活动。提姆形成具有P1和Pe2的异源二聚体,其结合时钟并阻断CROCK-BMAL1二聚体的激活以抑制每一个基因表达。此外,作为昼夜节律时钟的隐匿感光体的哭蛋白,作为昼夜节律钟的光独立抑制剂发挥作用。CRI1和CRI2通过与激活剂CROK-BMAL1、以及各种反馈抑制剂Pr1、Pr2和蒂姆负调控SCN组分。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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