FITC标记的核受体0相关蛋白B家族2抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的核受体0相关蛋白B家族2抗体
英文名称: Anti-NR0B2/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 10:32:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-NR0B2/FITC Conjugated antibody

FITC标记的核受体0相关蛋白B家族2抗体

 

产品编号 bs-4311R-FITC
英文名称 Anti-NR0B2/FITC
中文名称 FITC标记的核受体0相关蛋白B家族2抗体
别    名 NR0B2; NR0B2_HUMAN; Nr0b2a; Nuclear receptor subfamily 0 group B member 2; Nuclear receptor subfamily 0, group B, member 2a; Orphan nuclear receptor SHP; SHP; SHP-1; Shp1; Small heterodimer partner.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  染色质和核信号  信号转导  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NR0B2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
SHP is an orphan nuclear receptor containing the dimerization and ligand-binding domains found in other nuclear receptors, but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues, including fetal liver and adrenal gland, as well as adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARg. SHP interacts with nuclear receptors, including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function through competition and possibly transrepression via recruitment of putative corepressors. In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NFkB, suggesting that SHP is a modulatory component in the regulation of the transcriptional activities of NFkB. Lastly, negative feedback regulation of a hepatic bile acid transporter, NTCP, is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated damage in cholestatic conditions.

Function:
Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts.

Subunit:
Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2. 

Subcellular Location:
Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus. 

Tissue Specificity:
Liver. Low levels of expression were detected in heart and pancreas.

DISEASE:
Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Similarity:
Belongs to the nuclear hormone receptor family. NR0 subfamily.

Database links:

Entrez Gene: 8431 Human

Omim: 604630 Human

SwissProt: Q15466 Human

Unigene: 427055 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

SHP是一种孤儿核受体,含有其他核受体中的二聚和配体结合结构域,但缺乏保守的DNA结合结构域。在肝脏和其他组织中,尤其是胎儿肝脏和肾上腺,以及脾脏和小肠,SHP特异表达。此外,SHP在小鼠巨噬细胞系RAW 264.7中高表达,但被oxLDL和13-HODE抑制,这是PPARG的配体。SHP与核受体相互作用,包括甲状腺受体、视黄酸受体(RAR和RXR)和雌***受体(ERA和厄尔布)。SHP通过至少三种机制作为这些受体的负调节器:通过二聚化抑制DNA结合,通过竞争竞争直接激活共激活因子功能,并通过招募假定的辅阻遏物可能进行阻遏作用。在oxLDL处理的静息巨噬细胞中,SHP作为NFKB的转录辅激活子,提示SHP是调节NFKB转录活性的调节成分。最后,通过胆汁酸激活的FXR控制肝胆汁酸转运蛋白NTCP的负反馈调节,以诱导肝细胞免受胆汁淤积条件下的胆汁酸介导的损伤。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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