FITC标记的分子生物钟调控蛋白NOC抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的分子生物钟调控蛋白NOC抗体
英文名称: Anti-Nocturnin/FITC
抗体货号: HZ-11444R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/12 11:58:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Nocturnin/FITC Conjugated antibody

FITC标记的分子生物钟调控蛋白NOC抗体

 

产品编号 bs-11444R-FITC
英文名称 Anti-Nocturnin/FITC
中文名称 FITC标记的分子生物钟调控蛋白NOC抗体
别    名 CCR4 carbon catabolite repression 4 like (S. cerevisiae); CCR4 protein homolog; CCRN4L; NOC; NOCT_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Nocturnin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responisble for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.

Function:
CCRN4L is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.

Similarity:
Belongs to the CCR4/nocturin family.

Database links:
Entrez Gene: 540641 Cow
Entrez Gene: 25819 Human
Entrez Gene: 171555 Rat
Omim: 608468 Human
SwissProt: Q9UK39 Human
Unigene: 480763 Human


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

夜曲蛋白是一种431氨基酸的昼夜脱腺苷酸酶,在广泛的组织中表达,肝脏、肾脏和睾丸中的丰度最大。Nocturnin在昼夜节律和饮食诱导肥胖中起着重要作用。夜光蛋白mRNA丰度呈现昼夜节律,黄昏后光感受器、脾脏、心脏、肾脏和肝脏达到峰值。NocTrin被认为是关掉涉及昼夜节律调节的基因的反应。在Xenopus视网膜感光细胞中,夜曲素的韵律调节被认为是由***酸化CREB控制的。缺乏Nocturnin的小鼠在高脂肪饮食中保持瘦肉,内脏脂肪减少,这表明该蛋白质也可能负责脂质代谢和脂肪储存。

 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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