FITC标记的神经颗粒素抗体上海沪震实业有限公司

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产品名称: FITC标记的神经颗粒素抗体
英文名称: Anti-Neurogranin/FITC
抗体货号: HZ-11435R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/7 11:24:00
详细资料:  实验方法技术资料
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诚信指数:932点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Neurogranin/FITC Conjugated antibody

FITC标记的神经颗粒素抗体

 

产品编号 bs-11435R-FITC
英文名称 Anti-Neurogranin/FITC
中文名称 FITC标记的神经颗粒素抗体
别    名 Calmodulin binding protein; Hng; NEUG(55-78); NEUG_HUMAN; Neurogranin (protein kinase C substrate); Ng; NG; NRGN; Protein kinase C substrate; RC3; BICKS.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 7.6kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NG/Neurogranin (30-78aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008].

Function:
Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium.

Tissue Specificity:
In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.

Post-translational modifications:
Phosphorylated at Ser-36 by PHK

Similarity:
Belongs to the neurogranin family.
Contains 1 collagen-like domain.
Contains 1 IQ domain.

Database links:

Entrez Gene: 616955 Cow

Entrez Gene: 4900 Human

Entrez Gene: 64011 Mouse

Entrez Gene: 64356 Rat

Omim: 602350 Human

SwissProt: P35722 Cow

SwissProt: Q92686 Human

SwissProt: P60761 Mouse

SwissProt: Q04940 Rat

Unigene: 524116 Human

Unigene: 335065 Mouse

Unigene: 11236 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

Neurogranin(NRGN)是神经元特异性大鼠RC3/神经颗粒蛋白基因的人类同源物。该基因编码一个突触后蛋白激酶底物,结合钙调素在没有钙。NRGN基因含有四个外显子和三个内含子。外显子1和2编码蛋白质和外显子3和4包含非翻译序列。提示NRGN是人脑中甲状腺***的直接靶点,这种基因表达的控制可以在发育过程中以及成年受试者中表现出甲状腺功能减退对精神状态的许多后果。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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