FITC标记的双氧化酶2/甲状腺氧化酶2抗体
产品名称： FITC标记的双氧化酶2/甲状腺氧化酶2抗体
英文名称： Anti-DUOX2/FITC
产品编号： HZ-11432R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DUOX2/FITC Conjugated antibody
FITC标记的双氧化酶2/甲状腺氧化酶2抗体
| 产品编号 | bs-11432R-FITC |
| 英文名称 | Anti-DUOX2/FITC |
| 中文名称 | FITC标记的双氧化酶2/甲状腺氧化酶2抗体 |
| 别 名 | Dual oxidase 2; Dual oxidase2; DUOX2; DUOX2_HUMAN; Large NOX 2; LNOX2; Long NOX 2; NADH/NADPH thyroid oxidase p138 tox; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; NOXEF2; p138 thyroid oxidase; P138 TOX; THOX2; Thyroid oxidase 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 细胞膜蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 173kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DUOX2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Dual oxidase 2 (DUOX2), also designated NADPH thyroid oxidase 2, p138 thyroid oxidase or large NOX2, localizes to the apical membrane of epithelial cells. DUOX1, also designated NADPH thyroid oxidase or large NOX1, and DUOX2 are multi-pass membrane proteins predominantly expressed in thyrocytes, tracheal surface epithelial cells as well as thyroid, colon, duodenum, trachea and bronchium. DUOX1 and DUOX2 generate hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. In mucosa, DUOX proteins are involved in thyroid hormone biosynthesis and lactoperoxidase-mediated antimicrobial defense. Defects in the gene encoding for DUOX2 cause congenital hypothyroidism (CH), a disorder characterized by a defect in hydrogen peroxide production in the thyroid gland. Function: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Subunit: Interacts with TXNDC11, TPO and CYBA. Subcellular Location: Apical cell membrane. Localizes to the apical membrane of epithelial cells. Tissue Specificity: Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis. Post-translational modifications: N-glycosylated. DISEASE: Defects in DUOX2 are a cause of thyroid dyshormonogenesis 6 (TDH6) [MIM:607200]. A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Similarity: In the N-terminal section; belongs to the peroxidase family. Contains 3 EF-hand domains. Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. Database links: Entrez Gene: 50506 Human Entrez Gene: 79107 Rat Omim: 606759 Human SwissProt: Q9NRD8 Human SwissProt: Q9ES45 Rat Unigene: 71377 Human Unigene: 55542 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
双氧化酶2（DUOX2）也被命名为NADPH甲状腺氧化酶2，P138甲状腺氧化酶或大NOX2，定位于上皮细胞的顶端膜。DUOX1也是NADPH甲状腺氧化酶或大NOX1，DuOX2是多细胞膜蛋白，主要在甲状腺细胞、气管上皮细胞以及甲状腺、结肠、十二指肠、气管和支气管中表达。DuOX1和DuOX2产生过氧化氢，这是甲状腺过氧化物酶和乳过氧化物酶的关键。在粘膜中，Duox蛋白参与甲状腺激素生物合成和乳过氧化物酶介导的抗菌防御。Dux2基因的缺陷导致先天性甲状腺功能减退症（CH），其特征是甲状腺中过氧化氢产生的缺陷。