FITC标记的双氧化酶1/甲状腺氧化酶1抗体
产品名称： FITC标记的双氧化酶1/甲状腺氧化酶1抗体
英文名称： Anti-DUOX1/FITC
产品编号： HZ-11431R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DUOX1/FITC Conjugated antibody
FITC标记的双氧化酶1/甲状腺氧化酶1抗体
| 产品编号 | bs-11431R-FITC |
| 英文名称 | Anti-DUOX1/FITC |
| 中文名称 | FITC标记的双氧化酶1/甲状腺氧化酶1抗体 |
| 别 名 | Dual oxidase 1; Dual oxidase 1 precursor; DUOX1; EC 1.11.1; EC 1.6.3.1; Flavoprotein NADPH oxidase; Large NOX 1; LNOX1; Long NOX 1; MGC138840; MGC138841; NADPH thyroid oxidase 1; Nicotinamide adenine dinucleotide phosphate oxidase; NOXEF1; THOX1; Thyroid oxidase 1; DUOX1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 175kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DUOX1 (1-100aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Dual oxidase 1 (DUOX1), a homolog of glycoprotein p91Phox, is expressed in airway epithelium and generates reactive oxygen species (ROS). DUOX1 is a multi-pass membrane protein predominantly expressed in thyrocytes and tracheal surface epithelial cells, as well as thyroid, trachea and bronchium. DUOX1 generates hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. It is also involved in thyroid hormone synthesis and lactoperoxidase-mediated antimicrobial defense in mucosa. DUOX1, which also plays a role in mucin expression, is widely expressed in fetal tissues. Function: The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene (from EntrezGene). Subunit: Interacts with TXNDC11, TPO and CYBA. Subcellular Location: Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells. Tissue Specificity: Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart. Post-translational modifications: N-glycosylated. Similarity: In the N-terminal section; belongs to the peroxidase family. Contains 3 EF-hand domains. Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. Database links: Entrez Gene: 53905 Human Entrez Gene: 99439 Mouse Entrez Gene: 266807 Rat Omim: 606758 Human SwissProt: Q9NRD9 Human SwissProt: Q8CIY2 Rat Unigene: 272813 Human Unigene: 108582 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
双氧化酶1（DUOX1）是一种糖蛋白P91PHOX同系物，在气道上皮中表达，并产生活性氧（ROS）。DUOX1是一种多道膜蛋白，主要表达于甲状腺细胞和气管表面上皮细胞，以及甲状腺、气管和支气管。DUOX1产生过氧化氢，这是至关重要的甲状腺过氧化物酶和乳过氧化物酶。它还参与了甲状腺激素合成和乳过氧化物酶介导的黏膜防御。DuOX1在粘蛋白表达中起重要作用，在胎儿组织中广泛表达。