FITC标记的双氧化酶1/甲状腺氧化酶1抗体上海沪震实业有限公司

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产品名称: FITC标记的双氧化酶1/甲状腺氧化酶1抗体
英文名称: Anti-DUOX1/FITC
抗体货号: HZ-11431R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/9/5 14:34:00
详细资料:  实验方法技术资料
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诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-DUOX1/FITC Conjugated antibody

FITC标记的双氧化酶1/甲状腺氧化酶1抗体

 

产品编号 bs-11431R-FITC
英文名称 Anti-DUOX1/FITC
中文名称 FITC标记的双氧化酶1/甲状腺氧化酶1抗体
别    名 Dual oxidase 1; Dual oxidase 1 precursor; DUOX1; EC 1.11.1; EC 1.6.3.1; Flavoprotein NADPH oxidase; Large NOX 1; LNOX1; Long NOX 1; MGC138840; MGC138841; NADPH thyroid oxidase 1; Nicotinamide adenine dinucleotide phosphate oxidase; NOXEF1; THOX1; Thyroid oxidase 1; DUOX1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  信号转导  生长因子和***  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 175kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DUOX1 (1-100aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Dual oxidase 1 (DUOX1), a homolog of glycoprotein p91Phox, is expressed in airway epithelium and generates reactive oxygen species (ROS). DUOX1 is a multi-pass membrane protein predominantly expressed in thyrocytes and tracheal surface epithelial cells, as well as thyroid, trachea and bronchium. DUOX1 generates hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. It is also involved in thyroid hormone synthesis and lactoperoxidase-mediated antimicrobial defense in mucosa. DUOX1, which also plays a role in mucin expression, is widely expressed in fetal tissues.

Function:
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX2. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. Two alternatively spliced transcript variants encoding the same protein have been described for this gene (from EntrezGene).

Subunit:
Interacts with TXNDC11, TPO and CYBA.

Subcellular Location:
Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.

Tissue Specificity:
Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.

Post-translational modifications:
N-glycosylated.

Similarity:
In the N-terminal section; belongs to the peroxidase family.
Contains 3 EF-hand domains.
Contains 1 FAD-binding FR-type domain.
Contains 1 ferric oxidoreductase domain. 

Database links:

Entrez Gene: 53905 Human

Entrez Gene: 99439 Mouse

Entrez Gene: 266807 Rat

Omim: 606758 Human

SwissProt: Q9NRD9 Human

SwissProt: Q8CIY2 Rat

Unigene: 272813 Human

Unigene: 108582 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

双氧化酶1(DUOX1)是一种糖蛋白P91PHOX同系物,在气道上皮中表达,并产生活性氧(ROS)。DUOX1是一种多道膜蛋白,主要表达于甲状腺细胞和气管表面上皮细胞,以及甲状腺、气管和支气管。DUOX1产生过氧化氢,这是至关重要的甲状腺过氧化物酶和乳过氧化物酶。它还参与了甲状腺***合成和乳过氧化物酶介导的黏膜防御。DuOX1在粘蛋白表达中起重要作用,在胎儿组织中广泛表达。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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