FITC标记的神经肽S受体1/G蛋白偶联受体154抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的神经肽S受体1/G蛋白偶联受体154抗体
英文名称: Anti-NPSR1/FITC
抗体货号: HZ-11430R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 11:03:00
详细资料:  实验方法技术资料
浏览人数:8
诚信指数:754点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
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上海·中国-上海
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产品详细描述

 Rabbit Anti-NPSR1/FITC Conjugated antibody

FITC标记的神经肽S受体1/G蛋白偶联受体154抗体

 

产品编号 bs-11430R-FITC
英文名称 Anti-NPSR1/FITC
中文名称 FITC标记的神经肽S受体1/G蛋白偶联受体154抗体
别    名 GPR154; ASRT2; G protein coupled receptor 154; G protein coupled receptor for asthma susceptibility; G protein coupled receptor PGR14; GPR 154; gpr154; GPRA; MVTR; Neuropeptide S receptor 1; Neuropeptide S receptor; nps receptor; NPSR 1; NPSR; NPSR1; PGR 14; PGR14; PGR-14; Vasopressin receptor related receptor 1; VRR 1; VRR1; NPSR1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  细胞膜受体  G蛋白偶联受体  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NPSR1 (201-300aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR154 (G-protein coupled receptor 154), also known as NPSR1 (neuropeptide S receptor), GPRA (G-protein coupled receptor for asthma susceptibility) or PGR14, is a 371 amino acid protein that is thought to play a role in autocrine or paracrine signaling pathways. Ubiquitously expressed, GPR154 exists as nine alternatively spliced isoforms. Defects in the gene encoding GPR154 is the cause of asthma-related traits type 2 (ASRT2). 

Function:
Neuropeptide S receptor 1 (GPR154) is a receptor for Neuropeptide S. It is expressed on the epithelia of several organs including the intestine, and appears to be upregulated in inflammation. It is upregulated in macrophages after antigen challenge and is involved in the pathogenesis of asthma and other IgE-mediated diseases. 

Subcellular Location:
Cell Membrane and Cytoplasmic

Tissue Specificity:
Ubiquitous. Isoform 1 is predominantly expressed in smooth muscle. Isoform 4 is predominantly expressed in epithelial cells. In bronchial biopsies, it is expressed in smooth muscle cells of asthma patients, but not in control patients; whereas in epithelial cells, its expression is consistently stronger in asthma patients.

DISEASE:
Defects in NPSR1 are a cause of asthma-related traits type 2 (ASRT2) [MIM:608584]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Database links:

Entrez Gene: 387129 Human

Entrez Gene: 319239 Mouse

Entrez Gene: 300458 Rat

Omim: 608595 Human

SwissProt: Q6W5P4 Human

SwissProt: Q8BZP8 Mouse

SwissProt: P0C0L6 Rat

Unigene: 652373 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

神经肽S(neuropeptide S,NPS)是2002年发现的一种神经肽,由20个氨基酸组成,通过激活其受体NPSR而发挥作用。NPS/NPSR系统参与调节觉醒和睡眠、焦虑、摄食、免疫等功能。神经肽S(neuropeptide S,NPS),通过激活其同源受体(NPSR),并引发细胞内 Ca2+动员,进而调控失眠和忧虑,具有提高实验动物的清醒程度以及有减少焦虑的作用
   

G蛋白偶联受体(GPRS),也称为七个跨膜受体,庚螺旋受体或7TM受体,包括在许多不同的刺激应答途径中发挥作用的超家族。G蛋白偶联受体将胞外信号转化为细胞内信号(G蛋白激活),并对各种信号分子如***和神经递质作出反应。GPR154(G蛋白偶联受体154),也称为NPSR1(神经肽S受体),GPRA(G蛋白偶联受体,哮*易感性)或PGR14,是一种371氨基酸蛋白,被认为在自分泌或旁分泌信号通路中起作用。无处不在表达,GPR154作为九个交替剪接的亚型存在。编码GPR154基因的缺陷是哮*相关性状2型(ASRT2)的原因。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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