FITC标记的转录激活蛋白CRSP9抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的转录激活蛋白CRSP9抗体
英文名称: Anti-CRSP9/FITC
抗体货号: HZ-11427R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 11:04:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-CRSP9/FITC Conjugated antibody

FITC标记的转录激活蛋白CRSP9抗体

 

产品编号 bs-11427R-FITC
英文名称 Anti-CRSP9/FITC
中文名称 FITC标记的转录激活蛋白CRSP9抗体
别    名 Cofactor required for Sp1 transcriptional activation subunit 9; CRSP complex subunit 9; CRSP33; hMED7; MED7; MED7_HUMAN; Mediator complex subunit 7; Mediator of RNA polymerase II transcription subunit 7; MGC12284; RNA polymerase transcriptional regulation mediator subunit 7 homolog; Transcriptional coactivator CRSP33; Activator recruited cofactor 34 kDa component; Activator-recruited cofactor 34 kDa component; ARC34.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CRSP9 (101-200aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include the SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes, and including the human proteins Srb7, Med6 (also designated DRIP33) and Med7 (also designated DRIP34) (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Med6 and Med7, as well as other components of SMCC, associate with coactivator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation (4,5). Additionally, SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity (6).

Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Subunit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Subcellular Location:
Nucleus.

Post-translational modifications:
Constitutively sumoylated.

Similarity:
Belongs to the Mediator complex subunit 7 family.

Database links:
UniProtKB/Swiss-Prot: O43513.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

在哺乳动物细胞中,转录部分由高分子量共激活复合物调节,该复合物介导转录激活剂和RNA聚合酶(1)之间的信号。这些复合物包括SMCC(SRB和ME蛋白辅因子复合体),其由与酵母转录介体复合物的多个组分同源的各种亚基组成,包括人蛋白SRB7、MED6(也指定DRIP33)和MED7(也被指定为DRI)。p34)(2,3)。SMCC通过RSb7与rNAPII(RNA聚合酶II)全酶关联,进而增强由DNA结合转录因子(4)诱导的基因特异性激活或抑制。MED6和MED7,以及SMCC的其他组分,与来自诱捕器(甲状腺***受体激活蛋白)复合物和滴注(维生素D受体相互作用蛋白)复合物的辅激活蛋白相关,以促进类固醇依赖性受体依赖性转录激活(4,5)。此外,SMCC与PC4(阳性辅因子4)相关联,以抑制与RNAPII活性无关的基础转录(6)。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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