FITC标记的神经肽S抗体
产品名称： FITC标记的神经肽S抗体
英文名称： Anti-Neuropeptide S/FITC
产品编号： HZ-11422R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Neuropeptide S/FITC Conjugated antibody
FITC标记的神经肽S抗体
| 产品编号 | bs-11422R-FITC |
| 英文名称 | Anti-Neuropeptide S/FITC |
| 中文名称 | FITC标记的神经肽S抗体 |
| 别 名 | NeuropeptideS; Neuropeptide-S; Neuropeptide S; NPS; NPS_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 10kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Neuropeptide S (70-89aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Neuropeptides are regulators of synaptic transmission and their effects are mediated by G-protein coupled receptors. NPS (Neuropeptide S) is a 20 amino acid peptide cleaved from a larger precursor that contains a hydrophobic signal peptide and proteolytic cleavage processing sites. The N-terminal residue of NPS is always a serine regardless of the species. NPS is predominantly found in the central nervous system and plays an important role regulating sleep/wake functions, locomotion, arousal/anxiety responses and food intake. NPS functions by binding and activating its receptor, NPSR, and increasing intracellular calcium levels thereby acting as an excitatory transmitter. In addition, NPS stimulates the hypothalamo-pituitary adrenal (HPA) axis via the release of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP). NPS and its receptor NPSR may also play a role in asthma pathogenesis. Function: FunctionModulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations. Subcellular Location: Secreted. Database links: Entrez Gene: 594857 Human Omim: 609513 Human SwissProt: P0C0P5 Cow SwissProt: P0C0P6 Human Unigene: 643423 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
神经肽是突触传递的调节因子，它们的作用是由G蛋白偶联受体介导的。NPS（神经肽S）是从含有疏水性信号肽和蛋白水解裂解处理位点的较大前体裂解的20个氨基酸肽。无论物种如何，NPS的N-末端残基总是丝氨酸。NPS主要存在于中枢神经系统中，在调节睡眠/觉醒功能、运动、觉醒/焦虑反应和食物摄取方面起着重要的作用。NPS通过结合和激活其受体、NPSR和增加细胞内钙水平而起到兴奋性发送器的作用。此外，NPS通过释放促肾上腺皮质激素释放因子（CRF）和精氨酸加压素（AVP）刺激下丘脑-垂体-肾上腺（HPA）轴。NPS及其受体NPSR也可能参与哮*的发病机制。