FITC标记的磷酸化内质网核信号转导蛋白a1抗体-抗体-抗体-生物在线
FITC标记的磷酸化内质网核信号转导蛋白a1抗体

FITC标记的磷酸化内质网核信号转导蛋白a1抗体

商家询价

产品名称: FITC标记的磷酸化内质网核信号转导蛋白a1抗体

英文名称: Anti-phospho-IRE1a (Ser 726)/FITC

产品编号: HZ-4308R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-phospho-IRE1a (Ser 726)/FITC Conjugated antibody 

FITC标记的磷酸化内质网核信号转导蛋白a1抗体

 

产品编号 bs-4308R-FITC
英文名称 Anti-phospho-IRE1a (Ser 726)/FITC
中文名称 FITC标记的磷酸化内质网核信号转导蛋白a1抗体
别    名 p-IRE1a (phospho-Ser 726); IRE1 (phospho S726) ; IRE1 alpha (p-Ser726); Endoplasmic reticulum (ER) to nucleus signalling 1; Endoplasmic reticulum to nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 1; Endoribonuclease; ER to nucleus signaling 1; ERN 1; ERN1; ERN1_HUMAN; hIRE 1p; hIRE1p; Inositol requiring 1; Inositol requiring protein 1; Inositol-requiring protein 1; IRE 1; IRE 1a; IRE 1P; Ire1 alpha; Ire1-alpha; IRE1a; Ire1alpha; IRE1P; MGC163277; Protein kinase/endoribonuclease; Serine/threonine protein kinase/endoribonuclease IRE1.ERN1_HUMAN   
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
产品类型 磷酸化抗体 
研究领域 细胞生物  信号转导  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 107kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human IRE1a around the phosphorylation site of Ser 726
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. 

Function:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Subunit:
Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1. Interacts with TAOK3 and TRAF2.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Tissue Specificity:
Ubiquitously expressed. High levels observed in pancreatic tissue. 

Post-translational modifications:
Autophosphorylated. 

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 KEN domain.
Contains 1 protein kinase domain. 

Database links:

Entrez Gene: 2081 Human

Entrez Gene: 78943 Mouse

Entrez Gene: 498013 Rat

Omim: 604033 Human

SwissProt: O75460 Human

SwissProt: Q9EQY0 Mouse

Unigene: 133982 Human

Unigene: 592041 Human

Unigene: 700027 Human

Unigene: 20452 Mouse

Unigene: 340943 Mouse

Unigene: 226435 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

内质网内腔中的蛋白质通过其N-末端结构域被激活,从而导致酶的自动激活。激活的内切核糖核酸酶结构域连接XBP1 mRNA以产生新的C-末端,将其转化为有效的未折叠蛋白反应转录激活因子并触发生长停滞和凋亡。