FITC标记的褐黑素相关蛋白ART抗体上海沪震实业有限公司

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产品名称: FITC标记的褐黑素相关蛋白ART抗体
英文名称: Anti-AGRP/FITC
抗体货号: HZ-11415R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/12 13:21:00
详细资料:  实验方法技术资料
浏览人数:29
诚信指数:1026点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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电话:
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产品详细描述

 Rabbit Anti-AGRP/FITC Conjugated antibody

FITC标记的褐黑素相关蛋白ART抗体

 

产品编号 bs-11415R-FITC
英文名称 Anti-AGRP/FITC
中文名称 FITC标记的褐黑素相关蛋白ART抗体
别    名 Agouti Related Protein Homolog; agouti signaling protein; agouti switch protein; Agouti-related protein; Agrp; AGRP_HUMAN; AGRT; ART; ASIP2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  神经生物学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 12kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AGRP (31-80aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. 

Function:
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. 

Subunit:
Interacts with melanocortin receptors MC3R, MC4R and MC5R.

Subcellular Location:
Secreted. Golgi apparatus lumen.

Tissue Specificity:
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

DISEASE:
Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.

Similarity:
Contains 1 agouti domain.

Database links:
UniProtKB/Swiss-Prot: O00253.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

这个基因encodes黑皮素- 3受体拮抗剂安of the和黑皮素4受体。EN appears to贮藏行为的下丘脑黑皮素受体调控的喂养路径和/或钙调intracellular,角色扮演和thus homeostasis体重。在这mutations have been late基因与肥胖相关的片集。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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