Rabbit Anti-AGRP/FITC Conjugated antibody
|别 名||Agouti Related Protein Homolog; agouti signaling protein; agouti switch protein; Agouti-related protein; Agrp; AGRP_HUMAN; AGRT; ART; ASIP2.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 神经生物学 信号转导|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||12kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human AGRP (31-80aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity.
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Interacts with melanocortin receptors MC3R, MC4R and MC5R.
Secreted. Golgi apparatus lumen.
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Contains 1 agouti domain.
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
这个基因encodes黑皮素- 3受体拮抗剂安of the和黑皮素4受体。EN appears to贮藏行为的下丘脑黑皮素受体调控的喂养路径和/或钙调intracellular，角色扮演和thus homeostasis体重。在这mutations have been late基因与肥胖相关的片集。