FITC标记的锌指蛋白318抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的锌指蛋白318抗体
英文名称: Anti-ZNF318/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/14 11:21:00
详细资料:  实验方法技术资料
浏览人数:27
诚信指数:824点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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电话:
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上海·中国-上海
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产品详细描述

 Rabbit Anti-ZNF318/FITC Conjugated antibody

FITC标记的锌指蛋白318抗体

 

产品编号 bs-11414R-FITC
英文名称 Anti-ZNF318/FITC
中文名称 FITC标记的锌指蛋白318抗体
别    名 Endocrine Regulatory Protein; HGNC13578; HRIHFB2436; ZFP318; Zinc Finger Protein 318; ZN318_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  神经生物学  信号转导  内分泌病  锌指蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 251kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZNF318 (1077-1125aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
ZNF318 is a 2279 amino acid endocrine regulatory protein that localizes to the nucleus. Highly expressed in testis, ovaries and kidneys, ZNF318 is a co-repressor of androgen receptor (AR)-mediated transcriptional activation and is thought to regulate transcription during spermatogenesis. ZNF318 interacts with the N-terminal domain of AR and contains two matrin-type zinc fingers. Two isoforms of ZNF318, designated TZF and TZF-L, are produced due to alternative splicing events. Each of these splice variants are thought to have unique roles in transcriptional regulation. While the TZF isoform functions as a repressor of AR-mediated transcriptional activation, the TZF-L isoform is thought to enhance AR-mediated transcriptional activation.

Function:
ZNF318 encodes a nuclear protein with a zinc finger motif of the Cys2-His2 type that is a novel corepressor of androgen receptor.

Subunit:
Interacts with the N-terminal domain of AR.

Subcellular Location:
Nuclear.

Tissue Specificity:
Expressed in endocrine tissue.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 2 matrin-type zinc fingers.

Database links:

Entrez Gene: 24149 Human

SwissProt: Q5VUA4 Human

SwissProt: Q99PP2 Mouse

Unigene: 509718 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

ZNF318是一种定位于细胞核的2279氨基酸内分泌调节蛋白。在睾丸、卵巢和肾脏中高表达,ZNF318是雄受体(AR)介导的转录激活的共阻遏物,并被认为在精子发生过程中调节转录。ZNF318与AR的N端结构域相互作用,含有两个苦参碱型锌指。ZNF318的两种异构体,指定TZF和TZF L,由于选择性剪接事件而产生。每个剪接变异体被认为在转录调控中具有独特的作用。虽然TZF亚型作为AR介导的转录激活的阻遏物,但TZF L亚型被认为增强AR介导的转录激活。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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