FITC标记的精氨酸酶2抗体
产品名称： FITC标记的精氨酸酶2抗体
英文名称： Anti-Arginase II/FITC
产品编号： HZ-11397R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Arginase II/FITC Conjugated antibody
FITC标记的精氨酸酶2抗体
| 产品编号 | bs-11397R-FITC |
| 英文名称 | Anti-Arginase II/FITC |
| 中文名称 | FITC标记的精氨酸酶2抗体 |
| 别 名 | ARG 2; ARG2; ARGI2_HUMAN; Arginase-2; Arginase 2Arginase2; Arginase liver; Arginase type II; Arginase II; ArginaseII; Arginase-II; Arginase1; Arginase-2, mitochondrial; Kidney-type arginase; Non-hepatic arginase; Type II arginase; . |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Arginase II |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Arginase I (also designated liver-type arginase), which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea (1). The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster (2-4). Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location (5,6). Specifically, arginase II localizes to the mitochondria (5,6). Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver (5,6). The human arginase II gene, which maps to chromosome 14q24.1, encodes a 354 amino acid protein (3,5-7). In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence (5,6). Function: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. Subunit: Homotrimer. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas. Similarity: Belongs to the arginase family. Database links: Entrez Gene: 384 Human Entrez Gene: 11847 Mouse Entrez Gene: 29215 Rat Omim: 107830 Human SwissProt: P78540 Human SwissProt: O08691 Mouse SwissProt: O08701 Rat Unigene: 226007 Human Unigene: 723133 Human Unigene: 3506 Mouse Unigene: 11055 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
精氨酸酶I（也被称为肝型精氨酸酶），其几乎只在肝脏中表达，催化精氨酸向鸟氨酸和尿素的转化（1）。人类精氨酸酶I基因，其映射到染色体6q23，编码322个氨基酸的蛋白质。精氨酸酶I作为同源三聚体存在并含有双核锰簇（2-4）。精氨酸酶II催化与精氨酸酶I相同的反应，但其组织特异性和亚细胞位置（5，6）不同。具体而言，精氨酸酶II定位到线粒体（5，6）。精氨酸酶II在非肝组织中表达，在肾脏中表达最高，但与精氨酸酶I不同，在肝脏（5，6）中不表达。人类精氨酸酶II基因，其映射到染色体14q24.1，编码354个氨基酸的蛋白质（3，5-7）。此外，精氨酸酶II含有推测的氨基末端线粒体定位序列（5，6）。