Rabbit Anti-Rho B/FITC Conjugated antibody
|别 名||Rh -related GTP binding protein RhoB; Rh -related GTP binding protein RhoC; RHOH6; Transforming protein RhoA; AA017882 antibody Aplysia ras related homolog 9 (RhoC); ARH9; ARHA; ARHB; ARHC; H6; MST081; MSTP08; Oncogene RHO H9; rhoC GTPase; Ras homolog 9 (RhoC); Ras homolog gene family, member A; Ras homolog gene family, member B; Ras homolog gene family, member C; Rho related GTP binding protein RhoC; RHO12; RHOB; RHOC; RHOH9; RP11-426L16.4; Small GTP binding protein RhoC; H9; Rho related GTP binding protein RhoB; ARH12; ARH6; H12.RHOB_HUMAN|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||细胞生物 信号转导 激酶和***酸酶|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||22kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human Rho B|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The Rho proteins interact directly with protein kinases which are likely to serve as downstream effector targets of the activated GTPase. The Rho family of GTPases are involved in the regulation of the actin skeleton. Activation of Rho to the GTP bound state promotes formation of stress fibers and is required for the formation and maintenance of focal adhesions. Pathways stimulated by cytokines, hormones and various forms of stress utilize p21 proteins of the Rho family. Possible mediators for these responses include protein kinase such as p120PKN, and p150 ROKa/Rho-A kinase, myosin light chain (MLC) phosphatase and PIP 5-kinase.
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13.
Rho A: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm; cytoskeleton. Rho B: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Rho C: Cell membrane; Lipid-anchor; Cytoplasmic side.
Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.
Belongs to the small GTPase superfamily. Rho family.
Entrez Gene: 395734 Chicken
Entrez Gene: 515118 Cow
Entrez Gene: 388 Human
Entrez Gene: 11852 Mouse
Entrez Gene: 100144503 Pig
Entrez Gene: 64373 Rat
Omim: 165370 Human
SwissProt: Q3ZBW5 Cow
SwissProt: P62745 Human
SwissProt: P62746 Mouse
SwissProt: P62747 Rat
Unigene: 502876 Human
Unigene: 687 Mouse
Unigene: 2042 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
Rho蛋白直接与蛋白激酶相互作用，这些蛋白激酶可能充当激活的GTPASs的下游效应靶。Rho家族的GTPASs参与调节肌动蛋白骨架。激活Rho到GTP结合状态促进了应力纤维的形成，并且对粘着斑的形成和维持是必需的。由细胞因子、***和各种应激形式刺激的途径利用Rho家族的P21蛋白。这些反应的可能介质包括蛋白激酶如p120 PKN，和p150 ROKA/RO-A激酶，肌球蛋白轻链（MLC）***酸酶和PIP-5-激酶。