FITC标记的胰岛素样生长因子2受体抗体上海沪震实业有限公司

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产品名称: FITC标记的胰岛素样生长因子2受体抗体
英文名称: Anti-IGF2R/M6PR/FITC
抗体货号: HZ-6670R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: Flow-Cyt=1:50-200 IF=1:50-200
更新时间: 2018/8/10 12:58:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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上海·中国-上海
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产品详细描述

 Rabbit Anti-IGF2R/M6PR/FITC Conjugated antibody

FITC标记的胰岛素样生长因子2受体抗体

 

英文名称 Anti-IGF2R/M6PR/FITC
中文名称 FITC标记的胰岛素样生长因子2受体抗体
别    名 300 kDa mannose 6-phosphate receptor; Cation independent mannose 6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CD222 antigen; CI Man 6 P receptor; CI Man-6-P receptor; CI MPR; CI-MPR; CIMPR; IGF 2 receptor; IGF 2R; IGF II receptor; IGF-II receptor; IGF2 receptor; IGF2R; *** like growth factor 2 receptor; *** like growth factor II receptor; ***-like growth factor 2 receptor; ***-like growth factor II receptor; M6P R; M6P/IGF2 receptor; M6P/IGF2R; M6PR; MPR 300; MPR300; MPRI; MPRI_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  信号转导  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 Flow-Cyt=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 300kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IGF2R
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Function:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Subunit:
Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3.

Subcellular Location:
Lysosome membrane. Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface.

Similarity:
Belongs to the MRL1/IGF2R family. 
Contains 1 fibronectin type-II domain.

Database links:

Entrez Gene: 281849 Cow

Entrez Gene: 3482 Human

Entrez Gene: 16004 Mouse

Entrez Gene: 25151 Rat

Omim: 147280 Human

SwissProt: P08169 Cow

SwissProt: P11717 Human

SwissProt: Q07113 Mouse

Unigene: 487062 Human

Unigene: 26553 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

从高尔基复合体和细胞表面向溶酶体转运***酸化溶酶体酶。含有***酸甘露聚糖残基的溶酶体酶与高尔基体中甘露糖-6-***酸受体特异性结合,所得的受体-配体复合物被转运到酸性前溶酶体区,其中低pH介导复合物的解离。这种受体也结合IGF2。通过结合DPP4作为T细胞共激活的正调控因子。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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