FITC标记的水通道蛋白0抗体上海沪震实业有限公司

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产品名称: FITC标记的水通道蛋白0抗体
英文名称: Anti-AQP0/FITC
抗体货号: HZ-6661R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/21 13:48:00
详细资料:  实验方法技术资料
浏览人数:6
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-AQP0/FITC Conjugated antibody

FITC标记的水通道蛋白0抗体

 

英文名称 Anti-AQP0/FITC
中文名称 FITC标记的水通道蛋白0抗体
别    名 AQP 0; AQP0; Aquaporin; Aquaporin0; Lens fiber major intrinsic protein; LIM 1; LIM1; LIM-1; Major intrinsic protein 26kD; Major intrinsic protein of lens fiber; MIP 26; MIP; MIP26; MP 26; MP26; MIP_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  发育生物学  神经生物学  信号转导  干细胞  通道蛋白  细胞粘附分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 29kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human AQP0
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein aquaporins. Aquaporin 0 or MIP26 (major intrinsic protein 26kD), and Aquaporin 1 has been the foundation of the growing family of aquaporins. The lens specific Aquaporin 0 represents up to 80% of total lens membrane protein. Defects in Aquaporin 0 are a cause of autosomal recessive congenital cataract. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane. Human Aquaporin 0 is a 263 amino acid transmembrane protein belonging to the MIP family. Aquaporin families of proteins are predicted to contain six transmembrane domains. The N and C terminus are predicted to be cytoplasmic.

Function:
Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Subunit:
Homotetramer. Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. During early stages of lens development, interacts through its C-terminal region with Cx56 and GJA8/Cx45.6.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Tissue Specificity:
Major component of lens fiber gap junctions.

Similarity:
Contains 1 homeobox DNA-binding domain.
Contains 2 LIM zinc-binding domains.

Database links:

Entrez Gene: 4284 Human

Entrez Gene: 17339 Mouse

Entrez Gene: 25480 Rat

Omim: 154050 Human

SwissProt: P30301 Human

SwissProt: P51180 Mouse

SwissProt: P09011 Rat

Unigene: 574026 Human

Unigene: 31625 Mouse

Unigene: 396469 Mouse

Unigene: 23532 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

水是所有活细胞的重要组成部分。有趣的是,组织膜表现出很大程度的透水性。哺乳动物红细胞、肾近端小管和Helle下降的瘦肢对水具有非常强的渗透性。水通过简单的扩散或通过特殊的蛋白水通道蛋白介导的促进转运机制穿过疏水性质膜。水通道蛋白0或MIP26(主要内源蛋白26KD)和水通道蛋白1一直是水通道蛋白家族的基础。晶状体特异性水通道蛋白0占总晶状体膜蛋白的80%。水通道蛋白0的缺陷是常染色体隐性遗传先天性白内障的原因之一。晶状体混浊突变(ROP)是一种抑制MIP靶向细胞膜的AA替代物。人水通道蛋白0是属于MIP家族的263氨基酸跨膜蛋白。蛋白质的水通道蛋白家族预测包含六个跨膜结构域。N和C末端被预测为细胞质。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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