FITC标记的Emerin蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的Emerin蛋白抗体
英文名称: Anti-Emerin/FITC
抗体货号: HZ-6660R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/9/2 16:43:00
详细资料:  实验方法技术资料
浏览人数:6
诚信指数:962点
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使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-Emerin/FITC Conjugated antibody

FITC标记的Emerin蛋白抗体

 

英文名称 Anti-Emerin/FITC
中文名称 FITC标记的Emerin蛋白抗体
别    名 EDMD; EMD; EMD_HUMAN; Emerin; Emery Dreifuss muscular dystrophy; STA.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Emerin (1-100aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Tissue specificity; Skeletal muscle, heart, colon, testis, ovary and pancreas.

Function:
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.

Subunit:
Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the nuclear inner membrane. Interacts with SUN1 and SUN2. Interacts with ACTB, SPTAN1, F-actin, CTNNB1 and beta-tubulin.

Subcellular Location:
Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.

Tissue Specificity:
Skeletal muscle, heart, colon, testis, ovary and pancreas.

Post-translational modifications:
Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.

DISEASE:
Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1) [MIM:310300]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.

Similarity:
Contains 1 LEM domain.

Database links:
UniProtKB/Swiss-Prot: P50402.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

稳定和促进核肌动蛋白皮质网络的形成。通过结合和稳定生长丝的尖端刺激体外肌动蛋白聚合。通过抑制β-连环素在细胞核中的积累来抑制β连环素的活性。通过影响β-连环蛋白的核积累通过CRM1依赖的出口途径。通过微管关联将中心体连接到核膜上。EMD和BAF是HIV-1感染的协同辅因子。EMD与病毒DNA的关联需要BAF和病毒整合酶的存在。病毒DNA与染色质的关联需要BAF和EMD的存在。适当的非甲烯基化前体蛋白A/C的定位需要。

 

组织特异性:骨骼肌、心脏、结肠、睾丸、卵巢和胰腺。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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