FITC标记的周期素B2抗体
产品名称： FITC标记的周期素B2抗体
英文名称： Anti-Cyclin B2/FITC
产品编号： HZ-6656R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Cyclin B2/FITC Conjugated antibody
FITC标记的周期素B2抗体
| 中文名称 | FITC标记的周期素B2抗体 |
| 别 名 | Cyclin-B2; CycB2; G2 mitotic specific cyclin B2; G2/mitotic specific cyclin B2; CCNB2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞周期蛋白 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cyclin B2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cyclin B2 belongs to a the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin B2 has been shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition. Subunit: Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Similarity: Belongs to the cyclin family. Cyclin AB subfamily. Database links: Entrez Gene: 9133 Human Entrez Gene: 12442 Mouse Entrez Gene: 363088 Rat Omim: 602755 Human SwissProt: O95067 Human SwissProt: P30276 Mouse Unigene: 194698 Human Unigene: 22592 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞周期蛋白B2属于高度保守的细胞周期蛋白家族，其成员的特征是通过细胞周期在蛋白质丰度上具有显著的周期性。细胞周期蛋白是CDK激酶的调节因子。不同的细胞周期蛋白表现出不同的表达和降解模式，这有助于每个有丝分裂事件的时间协调。细胞周期素B2已被证明在睾丸和脑，以及在几个白血病细胞系中表达，并被认为主要在控制生殖系减数分裂细胞周期中起作用。这种细胞周期蛋白结合CDK2和CDC2激酶，这两种激酶活性不同，一种出现在S期，另一种出现在G2期，从而调节细胞周期中的单独功能。这种细胞周期蛋白被发现与重要的细胞周期调控因子结合，如Rb家族蛋白、转录因子E2F-1和P21家族蛋白。