FITC标记的周期素B2抗体上海沪震实业有限公司

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产品名称: FITC标记的周期素B2抗体
英文名称: Anti-Cyclin B2/FITC
抗体货号: HZ-6656R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/7 11:56:00
详细资料:  实验方法技术资料
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诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-Cyclin B2/FITC Conjugated antibody 

FITC标记的周期素B2抗体

 

中文名称 FITC标记的周期素B2抗体
别    名 Cyclin-B2; CycB2; G2 mitotic specific cyclin B2; G2/mitotic specific cyclin B2; CCNB2_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  免疫学  细胞周期蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cyclin B2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Cyclin B2 belongs to a the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin B2 has been shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins.

Function:
Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Subunit:
Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

Similarity:
Belongs to the cyclin family. Cyclin AB subfamily.

Database links:

Entrez Gene: 9133 Human

Entrez Gene: 12442 Mouse

Entrez Gene: 363088 Rat

Omim: 602755 Human

SwissProt: O95067 Human

SwissProt: P30276 Mouse

Unigene: 194698 Human

Unigene: 22592 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

细胞周期蛋白B2属于高度保守的细胞周期蛋白家族,其成员的特征是通过细胞周期在蛋白质丰度上具有显著的周期性。细胞周期蛋白是CDK激酶的调节因子。不同的细胞周期蛋白表现出不同的表达和降解模式,这有助于每个有丝分裂事件的时间协调。细胞周期素B2已被证明在睾丸和脑,以及在几个白血病细胞系中表达,并被认为主要在控制生殖系减数分裂细胞周期中起作用。这种细胞周期蛋白结合CDK2和CDC2激酶,这两种激酶活性不同,一种出现在S期,另一种出现在G2期,从而调节细胞周期中的单独功能。这种细胞周期蛋白被发现与重要的细胞周期调控因子结合,如Rb家族蛋白、转录因子E2F-1和P21家族蛋白。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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