FITC标记的桥尾蛋白抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的桥尾蛋白抗体
英文名称: Anti-Gephyrin/FITC
抗体货号: HZ-6644R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/7/13 8:54:00
详细资料:  实验方法技术资料
浏览人数:11
诚信指数:790点
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使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
所在区域:
上海·中国-上海
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产品详细描述

 Rabbit Anti-Gephyrin/FITC Conjugated antibody

FITC标记的桥尾蛋白抗体

 

英文名称 Anti-Gephyrin/FITC
中文名称 FITC标记的桥尾蛋白抗体
别    名 Domain E; Domain G; GEPH; GEPH_HUMAN; GPH; GPHN; GPHRYN; Molybdopterin molybdenumtransferase; MPT adenylyltransferase; MPT Mo-transferase.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  信号转导  细胞粘附分子  细胞表面分子  细胞骨架  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 83kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gephyrin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The sub-membraneous region at the postsynaptic membrane contains a number of proteins critical for receptor targeting. Gephyrin is a microtubule-associated protein highly expressed in brain and localized to neuronal postsynaptic membranes. Gephyrin is essential for the postsynaptic localization of the inhibitory glycine receptor and is thought to anchor the receptor to subsynaptic microtubules. The protein is expressed in most mammalian tissues with predominant expression in brain. At least five additional splice variants of Gephyrin ranging in molecular weight have been identified in rat and human brain tissue.

Function:
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.

Subunit:
Homotrimer. Interacts with GABARAP (By similarity).

Subcellular Location:
Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Cytoplasmic face of glycinergic postsynaptic membranes (By similarity).

DISEASE:
Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:252150]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.

Similarity:
In the N-terminal section; belongs to the moaB/mog family.
In the C-terminal section; belongs to the moeA family.

Database links:
UniProtKB/Swiss-Prot: Q9NQX3.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

突触后膜的亚膜区含有大量的受体靶向蛋白。Gephyrin是一种微管相关蛋白,在脑内高度表达,定位于神经元突触后膜。Gephyrin对于抑制甘氨酸受体的突触后定位是必不可少的,并被认为锚定受体到突触下微管。蛋白在大多数哺乳动物组织中表达,在脑中主要表达。在大鼠和人脑组织中已经鉴定出至少五种具有分子量的Geurin附加剪接变异体。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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