Rabbit Anti-TP53I8/FITC Conjugated antibody
|别 名||Ei24; EI24_HUMAN; EPG4; Etoposide induced 2.4 mRNA; Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; PIG8; TP53I8; Tumor protein p53 inducible protein 8.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 肿瘤细胞生物标志物|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||39kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human TP53I8/EI24 (256-300aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy.
Interacts with BCL2.
Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.
Belongs to the EI24 family.
Entrez Gene: 9538 Human
Entrez Gene: 13663 Mouse
Entrez Gene: 300514 Rat
Omim: 605170 Human
SwissProt: O14681 Human
SwissProt: Q61070 Mouse
SwissProt: Q4KM77 Rat
Unigene: 643514 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
该基因在p53表达细胞中的表达高于对照细胞，是p53介导的细胞凋亡的早期诱导靶点。该基因编码的蛋白含有六个推测的跨膜结构域，通过Caspase 9和线粒体途径诱导细胞凋亡，可以抑制细胞生长。该基因位于人类染色体11q24，在癌症中经常发生改变的区域。选择性剪接结果在两个转录变体中编码不同的亚型。[ RefSeq，JUL 2008 ]提供。