FITC标记的肿瘤蛋白p53诱导蛋白8上海沪震实业有限公司

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产品名称: FITC标记的肿瘤蛋白p53诱导蛋白8
英文名称: Anti-TP53I8/FITC
抗体货号: HZ-6637R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/23 14:28:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
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上海·中国-上海
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产品详细描述

 Rabbit Anti-TP53I8/FITC Conjugated antibody

FITC标记的肿瘤蛋白p53诱导蛋白8

 

英文名称 Anti-TP53I8/FITC
中文名称 FITC标记的肿瘤蛋白p53诱导蛋白8
别    名 Ei24; EI24_HUMAN; EPG4; Etoposide induced 2.4 mRNA; Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; PIG8; TP53I8; Tumor protein p53 inducible protein 8.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  肿瘤细胞生物标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TP53I8/EI24 (256-300aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Function:
Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy.

Subunit:
Interacts with BCL2.

Subcellular Location:
Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.

DISEASE:
Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.

Similarity:
Belongs to the EI24 family.

Database links:

Entrez Gene: 9538 Human

Entrez Gene: 13663 Mouse

Entrez Gene: 300514 Rat

Omim: 605170 Human

SwissProt: O14681 Human

SwissProt: Q61070 Mouse

SwissProt: Q4KM77 Rat

Unigene: 643514 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

该基因在p53表达细胞中的表达高于对照细胞,是p53介导的细胞凋亡的早期诱导靶点。该基因编码的蛋白含有六个推测的跨膜结构域,通过Caspase 9和线粒体途径诱导细胞凋亡,可以抑制细胞生长。该基因位于人类染色体11q24,在癌症中经常发生改变的区域。选择性剪接结果在两个转录变体中编码不同的亚型。[ RefSeq,JUL 2008 ]提供。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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