FITC标记的肿瘤蛋白p53诱导蛋白8
产品名称： FITC标记的肿瘤蛋白p53诱导蛋白8
英文名称： Anti-TP53I8/FITC
产品编号： HZ-6637R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TP53I8/FITC Conjugated antibody
FITC标记的肿瘤蛋白p53诱导蛋白8
| 英文名称 | Anti-TP53I8/FITC |
| 中文名称 | FITC标记的肿瘤蛋白p53诱导蛋白8 |
| 别 名 | Ei24; EI24_HUMAN; EPG4; Etoposide induced 2.4 mRNA; Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; PIG8; TP53I8; Tumor protein p53 inducible protein 8. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TP53I8/EI24 (256-300aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. Function: Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy. Subunit: Interacts with BCL2. Subcellular Location: Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein. DISEASE: Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness. Similarity: Belongs to the EI24 family. Database links: Entrez Gene: 9538 Human Entrez Gene: 13663 Mouse Entrez Gene: 300514 Rat Omim: 605170 Human SwissProt: O14681 Human SwissProt: Q61070 Mouse SwissProt: Q4KM77 Rat Unigene: 643514 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因在p53表达细胞中的表达高于对照细胞，是p53介导的细胞凋亡的早期诱导靶点。该基因编码的蛋白含有六个推测的跨膜结构域，通过Caspase 9和线粒体途径诱导细胞凋亡，可以抑制细胞生长。该基因位于人类染色体11q24，在癌症中经常发生改变的区域。选择性剪接结果在两个转录变体中编码不同的亚型。[ RefSeq，JUL 2008 ]提供。