FITC标记的NFκB激活蛋白205抗体上海沪震实业有限公司

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产品名称: FITC标记的NFκB激活蛋白205抗体
英文名称: Anti-ZDHHC17/FITC
抗体货号: HZ-6628R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/21 12:41:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-ZDHHC17/FITC Conjugated antibody

FITC标记的NFκB激活蛋白205抗体

 

英文名称 Anti-ZDHHC17/FITC
中文名称 FITC标记的NFκB激活蛋白205抗体
别    名 HSPC294; Putative MAPK activating protein PM11; Putative NF kappa B activating protein 205; Zinc finger DHHC domain containing protein 17; DHHC domain containing 17; HIP14; HIP3; huntingtin interacting protein 14; huntingtin interacting protein 3; Huntingtin interacting protein H; HYPH; KIAA0946; ZDHHC 17; zinc finger; ZDH17_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 神经生物学  信号转导  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 73kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZDHHC17/HIP14 (394-440aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
ZDHHC17 is a neuronal palmitoyl transferase. Palmitoylation is critical for trafficking and function of signaling molecules, neurotransmitter receptors, and synaptic scaffolding proteins in neurons. ZDHHC17 causes cellular transformation. It has been shown that mRNA encoding ZDHHC17 is up-regulated in a number of types of human tumors, thus ZDHHC17 and other PATs (palmitoyl acyltransferases) are potential targets for new anticancer drugs.

Function:
Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport. 

Subunit:
Interacts (via ANK repeats) with HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.

Subcellular Location:
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.

Tissue Specificity:
Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes.

Post-translational modifications:
Autopalmitoylated. Autopalmitoylation has a regulatory role in ZDHHC17-mediated Mg(2+) transport.

Similarity:
Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
Contains 5 ANK repeats. 
Contains 1 DHHC-type zinc finger. 

Database links:
UniProtKB/Swiss-Prot: Q8IUH5.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

zdhhc17是一个neuronal棕榈酰转移酶。关键的方法是palmitoylation贩卖和函数信号分子,neurotransmitter受体,和synaptic scaffolding蛋白在神经元。zdhhc17细胞转化的原因。它已被秀,这是zdhhc17编码的mRNA的表达上调在一个数的类型的人类肿瘤,因此zdhhc17和其他拍(棕榈酰O-酰基转移酶)是潜在目标的新方法anticancer药物。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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