FITC标记的26S蛋白酶调节亚型抗体
产品名称： FITC标记的26S蛋白酶调节亚型抗体
英文名称： Anti-PSMC1/FITC
产品编号： HZ-6627R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-PSMC1/FITC Conjugated antibody
FITC标记的26S蛋白酶调节亚型抗体
| 英文名称 | Anti-PSMC1/FITC |
| 中文名称 | FITC标记的26S蛋白酶调节亚型抗体 |
| 别 名 | 26S protease regulatory subunit 4; P26S4; p56; Proteasome (prosome macropain) 26S subunit ATPase 1; Proteasome 26S ATPase subunit 1; Proteasome 26S subunit ATPase 1; PSMC 1; PSMC1; S4; PRS4_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PSMC1/Proteasome 19S S4 (401-440aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. Function: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Subunit: Interacts with SCA7. Interacts with NGLY1. Interacts with PAAF1. Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the AAA ATPase family. Database links: Entrez Gene: 5700 Human Entrez Gene: 19179 Mouse Entrez Gene: 117263 Rat Omim: 602706 Human SwissProt: P62191 Human SwissProt: P62192 Mouse SwissProt: P62193 Rat Unigene: 356654 Human Unigene: 157105 Mouse Unigene: 10526 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
26S蛋白酶体是由2个复合物、20S核心和19S调节器组成的高度有序结构的多金属蛋白酶复合物。20S核由28个不相同的亚基组成的4个环，2个环由7个α亚基组成，2个环由7个β亚基组成。19S调节剂由一个碱基组成，它含有6个ATPase亚基和2个非ATP酶亚基，和一个含有最多10个非ATPase亚基的盖子。蛋白酶体在高浓度的真核细胞中分布，在非溶酶体途径中ATP／泛素依赖的过程中裂解肽。一种修饰的蛋白酶体，免疫蛋白酶体的基本功能，是I类MHC肽的加工。该基因编码ATPase亚基中的一个，其成员具有ATPase家族，其具有伴侣样活性。该亚基和20S核心α亚基与乙型肝炎病毒X蛋白特异性地相互作用，乙型肝炎病毒X蛋白是病毒复制的关键蛋白。该亚基还与腺病毒E1A蛋白相互作用，这种相互作用改变蛋白酶体的活性。最后，该亚基与ATAX-7相互作用，提示蛋白酶体在脊髓小脑共济失调7型（渐进性神经退行性疾病）发展中的作用。