FITC标记的26S蛋白酶调节亚型抗体上海沪震实业有限公司

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产品名称: FITC标记的26S蛋白酶调节亚型抗体
英文名称: Anti-PSMC1/FITC
抗体货号: HZ-6627R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/14 14:49:00
详细资料:  实验方法技术资料
浏览人数:9
诚信指数:1084点
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-PSMC1/FITC Conjugated antibody

FITC标记的26S蛋白酶调节亚型抗体

 

英文名称 Anti-PSMC1/FITC
中文名称 FITC标记的26S蛋白酶调节亚型抗体
别    名 26S protease regulatory subunit 4; P26S4; p56; Proteasome (prosome macropain) 26S subunit ATPase 1; Proteasome 26S ATPase subunit 1; Proteasome 26S subunit ATPase 1; PSMC 1; PSMC1; S4; PRS4_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PSMC1/Proteasome 19S S4 (401-440aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. 

Function:
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Subunit:
Interacts with SCA7. Interacts with NGLY1. Interacts with PAAF1.

Subcellular Location:
Cytoplasm. Nucleus.

Similarity:
Belongs to the AAA ATPase family. 

Database links:

Entrez Gene: 5700 Human

Entrez Gene: 19179 Mouse

Entrez Gene: 117263 Rat

Omim: 602706 Human

SwissProt: P62191 Human

SwissProt: P62192 Mouse

SwissProt: P62193 Rat

Unigene: 356654 Human

Unigene: 157105 Mouse

Unigene: 10526 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

26S蛋白酶体是由2个复合物、20S核心和19S调节器组成的高度有序结构的多金属蛋白酶复合物。20S核由28个不相同的亚基组成的4个环,2个环由7个α亚基组成,2个环由7个β亚基组成。19S调节剂由一个碱基组成,它含有6个ATPase亚基和2个非ATP酶亚基,和一个含有最多10个非ATPase亚基的盖子。蛋白酶体在高浓度的真核细胞中分布,在非溶酶体途径中ATP/泛素依赖的过程中裂解肽。一种修饰的蛋白酶体,免疫蛋白酶体的基本功能,是I类MHC肽的加工。该基因编码ATPase亚基中的一个,其成员具有ATPase家族,其具有伴侣样活性。该亚基和20S核心α亚基与乙型肝炎病毒X蛋白特异性地相互作用,乙型肝炎病毒X蛋白是病毒复制的关键蛋白。该亚基还与腺病毒E1A蛋白相互作用,这种相互作用改变蛋白酶体的活性。最后,该亚基与ATAX-7相互作用,提示蛋白酶体在脊髓小脑共济失调7型(渐进性神经退行性疾病)发展中的作用。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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