FITC标记的Wnt信号受体FZD2蛋白抗体上海沪震实业有限公司

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产品名称: FITC标记的Wnt信号受体FZD2蛋白抗体
英文名称: Anti-Frizzled 2/FITC
抗体货号: HZ-6623R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/8/30 14:28:00
详细资料:  实验方法技术资料
浏览人数:19
诚信指数:932点
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-Frizzled 2/FITC Conjugated antibody

FITC标记的Wnt信号受体FZD2蛋白抗体

 

英文名称 Anti-Frizzled 2/FITC
中文名称 FITC标记的Wnt信号受体FZD2蛋白抗体
别    名 Frizzled homolog 2; Frizzled-2; Frizzled2; Fz 2; Fz-2; Fz2; FZD 2; FZD2; FZD2_HUMAN; FzE 2; FzE2; hFz 2; hFz2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  信号转导  干细胞  转录调节因子  G蛋白偶联受体  细胞表面分子  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Frizzled 2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled as well as several secreted mammalian frizzled-related proteins (FRPs) have been described. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy terminal Ser/Thr-xxx-Val motif. They function as receptors for Wnt and are generally coupled to G proteins. Expression of frizzled-2 can be observed in the fetal kidney and lung and in the adult ovary and colon. The Wnt/cGMP/Ca2+ pathway is mediated by frizzled-2 . It binds Wnt proteins and signals by activating the release of stored calcium. Expression of frizzled-2 is regulated by Angiotensin II. Activated frizzled-2 suppresses the activity of protein kinase G, and activates NFAT-dependent transcription, the phosphatidylinositol pathway and calcium sensitive enzymes.

Function:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular Location:
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.

Post-translational modifications:
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome (By similarity).

Similarity:
Belongs to the G-protein coupled receptor Fz/Smo family.
Contains 1 FZ (frizzled) domain.

Database links:

Entrez Gene: 2535 Human

Entrez Gene: 57265 Mouse

Entrez Gene: 64512 Rat

Omim: 600667 Human

SwissProt: Q14332 Human

SwissProt: Q9JIP6 Mouse

SwissProt: Q08464 Rat

Unigene: 142912 Human

Unigene: 597264 Human

Unigene: 36416 Mouse

Unigene: 92324 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

最初在果蝇中发现的卷曲基因参与了组织极性的发育。本文描述了卷曲的哺乳动物同源物以及几种分泌的哺乳动物卷曲相关蛋白(FRPS)。卷曲蛋白含有七个跨膜结构域,胞外区富含半胱氨酸结构域和羧基末端S/THR XXX VAL基序。它们作为Wnt的受体,通常与G蛋白结合。在胎儿肾脏和肺和***卵巢和结肠中可观察到FRZZED-2的表达。Wnt/cGMP/Ca2+通路是由FruZel-2介导的。它通过激活储存的钙释放来结合Wnt蛋白和信号。FRZZED-2的表达受到Angiotensin II的调控。激活的FruZED-2抑制蛋白激酶G的活性,并激活NFAT依赖的转录,***脂酰肌醇途径和钙敏感酶。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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