FITC标记的上游结合蛋白1抗体
产品名称: FITC标记的上游结合蛋白1抗体
英文名称: Anti-Upstream Binding Protein 1/FITC
产品编号: HZ-6730R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-Upstream Binding Protein 1/FITC Conjugated antibody
FITC标记的上游结合蛋白1抗体
英文名称 | Anti-Upstream Binding Protein 1/FITC |
中文名称 | FITC标记的上游结合蛋白1抗体 |
别 名 | LBP 1a; Cp2b; DKFZp686L1745; LBP 1a; LBP 1B; LBP1; LBP1A; LBP1B; NF2d9; Upstream binding protein 1; Transcription factor LBP-1; UBIP1_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 信号转导 转录调节因子 结合蛋白 表观遗传学 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 60kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Upstream Binding Protein 1 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. Function: UBP1 is an important SF1 independent transcriptional activator stimulating P450scc expression in human placental JEG 3 cells. Subunit: Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1. Subcellular Location: Nucleus. Tissue Specificity: Expressed in adrenal tissue, JEG-3, NCI-H295A, HepG2 and HeLa cell lines. Similarity: Belongs to the grh/CP2 family. CP2 subfamily. Database links: Entrez Gene: 7342 Human Entrez Gene: 22221 Mouse Entrez Gene: 301038 Rat Omim: 609784 Human SwissProt: Q86Y57 Human SwissProt: Q9NZI7 Human SwissProt: Q60786 Mouse SwissProt: Q811S7 Mouse SwissProt: Q8BH21 Mouse Unigene: 118041 Human Unigene: 729120 Human Unigene: 28052 Mouse Unigene: 386808 Mouse Unigene: 15705 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
作为启动子依赖于上下文的转录激活因子的功能。调节CYP11A1的胎盘表达。参与调节红系细胞α-珠蛋白基因的表达。α-珠蛋白启动子在红系细胞中的激活是通过与TFCP2的协同作用(通过相似性)。参与调节红系细胞α-珠蛋白基因的表达。强烈地结合HIV-1启动位点周围的序列,并在TATA盒上较弱。通过抑制TFIID与TATA盒的结合抑制HIV-1转录。