FITC标记的同源盒蛋白Meis1抗体-抗体-抗体-生物在线
FITC标记的同源盒蛋白Meis1抗体

FITC标记的同源盒蛋白Meis1抗体

商家询价

产品名称: FITC标记的同源盒蛋白Meis1抗体

英文名称: Anti-MEIS1/FITC

产品编号: HZ-6680R-FITC

产品价格: null

产品产地: 中国/上海

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: IF=1:50-200

上海沪震实业有限公司
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 Rabbit Anti-MEIS1/FITC Conjugated antibody

FITC标记的同源盒蛋白Meis1抗体

 

英文名称 Anti-MEIS1/FITC
中文名称 FITC标记的同源盒蛋白Meis1抗体
别    名 Meis1 myeloid ecotropic viral integration site 1 homolog mouse; Homeo box protein Meis1; Homeobox protein Meis1; Leukemogenic homolog protein; MEIS 1; Meis homeo box 1; Meis homeobox 1; Meis1; Meis1 mouse homolog; Meis1 myeloid ecotropic viral integration site 1 homolog; MEIS1 protein; MEIS1_HUMAN; myeloid ecotropic viral integration site 1 homolog.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 染色质和核信号  信号转导  干细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MEIS1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
Tissue specificity; Expressed at low level in normal immunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.

Function:
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.

Subunit:
Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed at low level in normalcimmunohepatopoietic tissues, including the fetal liver. Expressed in a subset of myeloid leukemia cell lines, with the highest expression seen in those with a megakaryocytic-erythroid phenotype. Also expressed at high levels in the cerebellum.

DISEASE:
Defects in MEIS1 could be a cause of susceptibility to restless legs syndrome type 7 (RLS7) [MIM:612853]. Restless legs syndrome (RLS) is a neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation.

Similarity:
Belongs to the TALE/MEIS homeobox family. 
Contains 1 homeobox DNA-binding domain. 

Database links:

Entrez Gene: 4211 Human

Entrez Gene: 17268 Mouse

Entrez Gene: 686117 Rat

Entrez Gene: 170446 Zebrafish

Omim: 601739 Human

SwissProt: O00470 Human

SwissProt: Q60954 Mouse

Unigene: 526754 Human

Unigene: 603755 Human

Unigene: 356578 Mouse

Unigene: 445192 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

作为PAX6的转录调控因子。作为PBX1或PBX2复合物中PF4的转录激活因子。造血需要,巨核细胞谱系发育和血管构图。可能是HOXA7和HOXA9诱导髓细胞白血病的辅助因子。

 

组织特异性;在正常免疫肝组织包括胎儿肝脏中低水平表达。在髓系白血病细胞系的一个子集中表达,在巨核红系表型中表达最高。也在小脑中高水平表达。