FITC标记的GATA结合蛋白2抗体上海沪震实业有限公司

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产品名称: FITC标记的GATA结合蛋白2抗体
英文名称: Anti-GATA2/FITC
抗体货号: HZ-6616R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/16 12:28:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-GATA2/FITC Conjugated antibody

FITC标记的GATA结合蛋白2抗体

 

英文名称 Anti-GATA2/FITC
中文名称 FITC标记的GATA结合蛋白2抗体
别    名 GATA-2; GATA 2; GATA Binding Protein 2; GATA-binding protein 2; Gata2; GATA2_HUMAN; MGC2306; NFE 1B; NFE1B.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  信号转导  干细胞  转录调节因子  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GATA-2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

Function:
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

Subcellular Location:
Nucleus.

Tissue Specificity:
Endothelial cells.

DISEASE:
Defects in GATA2 are the cause of dendritic cell monocyte lymphocyte B and natural killer lymphocyte deficiency (DCML) [MIM:614172]. DCML is an immunodeficiency disease characterized by profoundly decreased or absent monocytes, B-lymphocytes, natural killer lymphocytes, and circulating and tissue dendritic cells, with little or no effect on T-cell numbers. Clinical features of DCML include susceptibility to disseminated non-tuberculous mycobacterial infections, papillomavirus infections, opportunistic fungal infections, and pulmonary alveolar proteinosis. Bone marrow hypocellularity and dysplasia of myeloid, erythroid, and megakaryocytic lineages are present in most patients, as are karyotypic abnormalities, including monosomy 7 and trisomy 8.

Similarity:
Contains 2 GATA-type zinc fingers.

Database links:

Entrez Gene: 416018 Chicken

Entrez Gene: 2624 Human

Entrez Gene: 14461 Mouse

Entrez Gene: 25159 Rat

Omim: 137295 Human

SwissProt: P23824 Chicken

SwissProt: P23769 Human

SwissProt: O09100 Mouse

SwissProt: Q924Y4 Rat

Unigene: 367725 Human

Unigene: 34322 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

加塔家族的成员共享保守的锌指DNA结合结构域,并能够结合WGATAR共识序列。GATA-1是红系特异性的,负责调控红系基因转录。它是红系血统的重要组成部分。GATA-2在胚胎脑和肝、HeLa和内皮细胞以及红系细胞中表达。用改良的GATA共识序列AgATCTA进行的研究表明,GATA-2和GATA-3识别这种突变的一致性,而GATA-1对这一序列的识别能力较差。这表明GATA-2和GATA-3比GATA-1更广泛的调节能力。GATA-3在T淋巴细胞中高表达。GATA-4、GATA-5和GATA-6是转录因子家族的一个亚家族。GATA-4和GATA-6均存在于心脏、胰腺和卵巢;肺和肝组织表现为GATA-6,但不表达GATA-4。GATA-5的表达已在分化的心脏和肠道组织中观察到,并且在心脏的整个发育过程中都存在。虽然各种GATA转录因子的表达模式可能重叠,但尚不清楚的是,GATA因子如何能够在结合其合适的靶位点中进行鉴别。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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