FITC标记的G蛋白偶联受体MRGX1抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的G蛋白偶联受体MRGX1抗体
英文名称: Anti-MRGX1/FITC
抗体货号: HZ-6606R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/7/13 10:00:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
021-60345367
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021-31320307
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上海·中国-上海
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产品详细描述

 Rabbit Anti-MRGX1/FITC Conjugated antibody

FITC标记的G蛋白偶联受体MRGX1抗体

 

英文名称 Anti-MRGX1/FITC
中文名称 FITC标记的G蛋白偶联受体MRGX1抗体
别    名 MRGPRC; G protein coupled receptor MRGX1; G protein coupled receptor SNSR3; GPCR; Mas related G protein coupled receptor member X1; MAS related gene MRGX1; MAS related GPR member X1; MRGPRX1; MRGX1; Sensory neuron specific G protein coupled receptor 3/4; Seven transmembrane helix receptor; SNSR3; SNSR4; MRGX1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  转录调节因子  G蛋白偶联受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MRGX1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the function of nociceptive neurons. This integral membrane protein may also regulate nociceptor development and/or the sensation or modulation of pain. There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons.

Function:
MRGX1 is an opiod receptor that has been reported exclusively in dorsal root ganglion. MRGX1 is probably involved in the function of nociceptive neurons and may regulate nociceptor function and/or development, including the sensation or modulation of pain. It is potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells.

Subcellular Location:
Cell Membrane; Multi-pass membrane protein.

Tissue Specificity:
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Database links:

Entrez Gene: 259249 Human

Omim: 607227 Human

SwissProt: Q96LB2 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

MAS相关G蛋白偶联受体成员X1(MRGX)是一种参与感觉伤害性神经元功能的感觉神经元特异性G蛋白偶联受体。这种整合的膜蛋白也可以调节伤害感受器的发育和/或疼痛的感觉或调节。在人类MRGX家族中有四个成员(MRGX1-4)。MRGX1和MRGX2受体同时刺激GαQ和GαI调控通路,而MRGX3和MRGX4受体主要激活GαQ调节通路。GαQ蛋白参与MRGX受体下游的钙信号通路。MRGX受体是独特的,它们在小背根和三叉神经感觉神经元的一个子集中表达。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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