FITC标记的G蛋白偶联受体MRGX1抗体
产品名称: FITC标记的G蛋白偶联受体MRGX1抗体
英文名称: Anti-MRGX1/FITC
产品编号: HZ-6606R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-MRGX1/FITC Conjugated antibody
FITC标记的G蛋白偶联受体MRGX1抗体
英文名称 | Anti-MRGX1/FITC |
中文名称 | FITC标记的G蛋白偶联受体MRGX1抗体 |
别 名 | MRGPRC; G protein coupled receptor MRGX1; G protein coupled receptor SNSR3; GPCR; Mas related G protein coupled receptor member X1; MAS related gene MRGX1; MAS related GPR member X1; MRGPRX1; MRGX1; Sensory neuron specific G protein coupled receptor 3/4; Seven transmembrane helix receptor; SNSR3; SNSR4; MRGX1_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 信号转导 转录调节因子 G蛋白偶联受体 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, |
产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 36kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human MRGX1 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the function of nociceptive neurons. This integral membrane protein may also regulate nociceptor development and/or the sensation or modulation of pain. There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. Function: MRGX1 is an opiod receptor that has been reported exclusively in dorsal root ganglion. MRGX1 is probably involved in the function of nociceptive neurons and may regulate nociceptor function and/or development, including the sensation or modulation of pain. It is potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. Subcellular Location: Cell Membrane; Multi-pass membrane protein. Tissue Specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. Database links: Entrez Gene: 259249 Human Omim: 607227 Human SwissProt: Q96LB2 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MAS相关G蛋白偶联受体成员X1(MRGX)是一种参与感觉伤害性神经元功能的感觉神经元特异性G蛋白偶联受体。这种整合的膜蛋白也可以调节伤害感受器的发育和/或疼痛的感觉或调节。在人类MRGX家族中有四个成员(MRGX1-4)。MRGX1和MRGX2受体同时刺激GαQ和GαI调控通路,而MRGX3和MRGX4受体主要激活GαQ调节通路。GαQ蛋白参与MRGX受体下游的钙信号通路。MRGX受体是独特的,它们在小背根和三叉神经感觉神经元的一个子集中表达。