FITC标记的乳腺癌相关蛋白2抗体上海沪震实业有限公司

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产品名称: FITC标记的乳腺癌相关蛋白2抗体
英文名称: Anti-BCAS2/FITC
抗体货号: HZ-
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/12 12:29:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
地址:
上海市杨浦区密云路1018号复旦科技园808室
邮编:
200612
电话:
021-60345367
传真:
021-31320307
联系人:
陈先生
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上海·中国-上海
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产品详细描述

 Rabbit Anti-BCAS2/FITC Conjugated antibody 

FITC标记的乳腺癌相关蛋白2抗体

 

英文名称 Anti-BCAS2/FITC
中文名称 FITC标记的乳腺癌相关蛋白2抗体
别    名 DNA amplified in mammary carcinoma 1 protein; Spliceosome associated protein SPF 27; bcas2; Breast carcinoma amplified sequence 2; Breast carcinoma-amplified sequence 2; DAM1; MGC7712; Pre mRNA splicing factor SPF27; Pre-mRNA-splicing factor spf27; SPF27_HUMAN; Spliceosome associated protein amplified in breast cancer; Spliceosome-associated protein SPF 27.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  肿瘤细胞生物标志物  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BCAS2 (162-210aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
BCAS2 is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligand-independent manner) with thyroid hormone receptor beta, ER alpha (estrogen receptor alpha), PR (progesterone receptor), and PPAR gamma (Peroxisome proliferator-activated receptor gamma). BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer.

Function:
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.

Subunit:
Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly in the complex with PRPF19, CDC5L and PLRG1.

Subcellular Location:
Nucleus, nucleolus.

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Belongs to the SPF27 family.

Database links:
UniProtKB/Swiss-Prot: O75934.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

BCAS2是一种广泛表达的核蛋白,最初被鉴定为在各种乳腺癌细胞系中被过度表达。CAS2现在已知是剪接体的一个组成部分,参与从mRNA前体去除内含子。BCAS2特异性(与配体无关)与甲状腺受体β、ERα(雌体α)、PR(孕受体)和PPARγ(过氧化物酶体增殖物激活受体γ)相互作用。BCAS2作为ER共激活子起作用,并且能够增强ER介导的转录。这提示BCAS2参与了乳腺癌的发生发展。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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