FITC标记的肾小球裂孔膜蛋白PDCN抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的肾小球裂孔膜蛋白PDCN抗体
英文名称: Anti-NPHS2/Podocin/FITC
抗体货号: HZ-6597R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/7/13 10:16:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-NPHS2/Podocin/FITC Conjugated antibody

FITC标记的肾小球裂孔膜蛋白PDCN抗体

 

英文名称 Anti-NPHS2/Podocin/FITC
中文名称 FITC标记的肾小球裂孔膜蛋白PDCN抗体
别    名 nephrosis 2, idiopathic, steroid resistant; NPHS2 gene; PDCN; Podocin; SRN1; PODO_HUMAN.  

Journal
PMID
IF
Application
Biology of Sex Differences (2015)
25729563
4.8400
FCM
 
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  细胞类型标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NPHS2/Podocin
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Podocin is an important member of a group of proteins shown to be associated with the slit diaphragm. Podocin belongs to the band 7 stomatin family of lipid raft-associated proteins. It is a hairpin like integral membrane protein with intracellular N and C termini. Podocin is located at the insertion site of the slit membrane, and is thought to act as a scaffold protein required to maintain or regulate the structural integrity of the slit diaphragm. It plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.

Subunit:
Interacts with nephrin/NPHS1 and KIRREL. Interacts directly with CD2AP. Interacts with DDN (By similarity).

Subcellular Location:
Cell membrane; Peripheral membrane protein.

Tissue Specificity:
Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli.

DISEASE:
Defects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2) [MIM:600995]. It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder.

Similarity:
Belongs to the band 7/mec-2 family.

Database links:
Entrez Gene: 7827 Human
Entrez Gene: 170484 Mouse
Entrez Gene: 170672 Rat
Omim: 604766 Human
SwissProt: Q9NP85 Human
SwissProt: Q91X05 Mouse
SwissProt: Q8K4G9 Rat
Unigene: 412710 Human
Unigene: 289099 Mouse
Unigene: 86433 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

Podoin是一组与缝隙隔膜相关的蛋白质的重要成员。Podoin属于脂筏相关蛋白的带7家族。它是一种发夹状的膜蛋白,具有细胞内的N和C末端。Podoin位于缝隙膜的插入位点,被认为是维持或调节狭缝隔膜结构完整性所需的支架蛋白。它在肾小球通透性的调节中起作用,可能作为细胞膜和细胞骨架之间的连接体。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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