FITC标记的肾小球裂孔膜蛋白PDCN抗体
产品名称: FITC标记的肾小球裂孔膜蛋白PDCN抗体
英文名称: Anti-NPHS2/Podocin/FITC
产品编号: HZ-6597R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
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Rabbit Anti-NPHS2/Podocin/FITC Conjugated antibody
FITC标记的肾小球裂孔膜蛋白PDCN抗体
英文名称 | Anti-NPHS2/Podocin/FITC |
中文名称 | FITC标记的肾小球裂孔膜蛋白PDCN抗体 |
别 名 | nephrosis 2, idiopathic, steroid resistant; NPHS2 gene; PDCN; Podocin; SRN1; PODO_HUMAN. |
Journal
PMID
IF
Application
Biology of Sex Differences (2015)
25729563
4.8400
FCM
|
|
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 细胞生物 信号转导 细胞类型标志物 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 42kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human NPHS2/Podocin |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Podocin is an important member of a group of proteins shown to be associated with the slit diaphragm. Podocin belongs to the band 7 stomatin family of lipid raft-associated proteins. It is a hairpin like integral membrane protein with intracellular N and C termini. Podocin is located at the insertion site of the slit membrane, and is thought to act as a scaffold protein required to maintain or regulate the structural integrity of the slit diaphragm. It plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Subunit: Interacts with nephrin/NPHS1 and KIRREL. Interacts directly with CD2AP. Interacts with DDN (By similarity). Subcellular Location: Cell membrane; Peripheral membrane protein. Tissue Specificity: Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli. DISEASE: Defects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2) [MIM:600995]. It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder. Similarity: Belongs to the band 7/mec-2 family. Database links: Entrez Gene: 7827 Human Entrez Gene: 170484 Mouse Entrez Gene: 170672 Rat Omim: 604766 Human SwissProt: Q9NP85 Human SwissProt: Q91X05 Mouse SwissProt: Q8K4G9 Rat Unigene: 412710 Human Unigene: 289099 Mouse Unigene: 86433 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Podoin是一组与缝隙隔膜相关的蛋白质的重要成员。Podoin属于脂筏相关蛋白的带7家族。它是一种发夹状的膜蛋白,具有细胞内的N和C末端。Podoin位于缝隙膜的插入位点,被认为是维持或调节狭缝隔膜结构完整性所需的支架蛋白。它在肾小球通透性的调节中起作用,可能作为细胞膜和细胞骨架之间的连接体。