FITC标记的着丝粒蛋白B抗体
产品名称： FITC标记的着丝粒蛋白B抗体
英文名称： Anti-CENPB/FITC
产品编号： HZ-6595R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CENPB/FITC Conjugated antibody
FITC标记的着丝粒蛋白B抗体
| 英文名称 | Anti-CENPB/FITC |
| 中文名称 | FITC标记的着丝粒蛋白B抗体 |
| 别 名 | CENP B; CENP-B; centromere autoantigen B; Centromere protein B; Major centromere autoantigen B; CENPB_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 染色质和核信号 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CENPB (321-360aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene product is a highly conserved protein associated with the centromere. It is a DNA-binding protein containing a helix loop helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17 bp sequence (CENPB box) in the centromeric satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. (referenced from Entrez Gene) Function: Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. Subunit: Homodimer. Interacts with CENPT. Subcellular Location: Nucleus. Chromosome, centromere. Similarity: Contains 1 HTH CENPB-type DNA-binding domain. Contains 1 HTH psq-type DNA-binding domain. Database links: UniProtKB/Swiss-Prot: P07199.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
该基因产物是与着丝粒相关的高度保守的蛋白质。它是一个DNA结合蛋白，其包含在N端的螺旋-环-螺旋- DNA结合基序，以及在C-末端的二聚域。DNA结合域识别并结合着丝粒卫星DNA中的17 bp序列（CENPB盒）。该蛋白在间期核和有丝分裂染色体上的特定着丝粒结构的组装中发挥重要作用。它也被认为是由抗着丝粒抗体患者血清识别的主要着丝粒自身抗原。（Entrez Gene引用）