FITC标记的17-β-羟脱氢酶6抗体
产品名称： FITC标记的17-β-羟脱氢酶6抗体
英文名称： Anti-HSD17B6/FITC
产品编号： HZ-6592R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-HSD17B6/FITC Conjugated antibody
FITC标记的17-β-羟脱氢酶6抗体
| 英文名称 | Anti-HSD17B6/FITC |
| 中文名称 | FITC标记的17-β-羟脱氢酶6抗体 |
| 别 名 | 17-beta-HSD 6; 17-beta-HSD6; 17-beta-hydroxysteroid dehydrogenase type 6; 3 hydroxysteroid epimerase; 3(alpha >beta) hydroxysteroid epimerase; 3(alpha >beta) hydroxysteroid epimerasel; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; H17B6_HUMAN; HSD17B6; HSE; Hydroxysteroid (17 beta) dehydrogenase 6; Hydroxysteroid (17 beta) dehydrogenase 6 homolog (mouse); Hydroxysteroid 17 beta dehydrogenase 6; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase; NAD+ dependent 3 alpha hydroxysteroid dehydrogenase; Oxidative 3 alpha hydroxysteroid dehydrogenase; Oxidative 3-alpha hydroxysteroid dehydrogenase; Oxidoreductase; Retinol dehydrogenase; RODH; SDR9C6;Short chain dehydrogenase/reductase family 9C, member 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 信号转导 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HSD17B6 (70-115aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. Tissue specificity; Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. Sequence similarities; Belongs to the short-chain dehydrogenases/reductases (SDR) family. Subcellular Location: Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side (Potential). Tissue Specificity: Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. Database links: Entrez Gene: 8630 Human Entrez Gene: 27400 Mouse Entrez Gene: 286964 Rat Omim: 606623 Human SwissProt: Q3T001 Cow SwissProt: O14756 Human SwissProt: Q9R092 Mouse SwissProt: O54753 Rat Unigene: 524513 Human Unigene: 26719 Mouse Unigene: 10857 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NAD依赖的氧化还原酶具有广泛的底物特异性，显示出氧化和还原活性（体外）。有17β-羟类固醇脱氢酶活性对各种类固醇（体外）。将5-α-雄甾-3-α，17β-二醇转化为雄酮和雌二醇至雌酮（体外）。对雄酮具有体外α-羟类固醇脱氢酶活性（体外）。对全反式视黄醇具有视黄醇脱氢酶活性（体外）。可将雄激素转化为表雄酮。首先将Androsterone氧化为5-α-雄甾-3，17-二酮，然后还原成表雄酮。可以作用于C-19和C-21 -3α-羟基甾体。
组织特异性：在肝和前列腺中检测到（蛋白水平）。在成人肝脏、肺、脑、胎盘、前列腺、肾上腺、睾丸、乳腺、脾脏、脊髓和子宫中检测到。在尾状核、杏仁核、胼胝体、海马、黑质、丘脑等较低水平。检测胎儿肺、肝、脑。
序列相似性，属于短链脱氢酶/还原酶（SDR）家族。