FITC标记的支链氨基酸转氨酶2抗体
产品名称： FITC标记的支链氨基酸转氨酶2抗体
英文名称： Anti-BCAT2/FITC
产品编号： HZ-6589R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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- 邮编 : 200612
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Rabbit Anti-BCAT2/FITC Conjugated antibody
FITC标记的支链氨基酸转氨酶2抗体
| 英文名称 | Anti-BCAT2/FITC |
| 中文名称 | FITC标记的支链氨基酸转氨酶2抗体 |
| 别 名 | BCAM; BCAT 2; BCATM; BCT2; Branched chain aminotransferase 2, mitochondrial; ECA40; Placental protein 18; PP18. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 41kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BCAT2/BCAM |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Class-IV pyridoxal-phosphate-dependent aminotransferase family members ECA39 and BCAT2 are both enzymes that catalyze the first reaction in the catabolism of the essential branched chain amino acids valine, leucine and isoleucine. ECA39, also known as BCAT1 (branched-chain-amino-acid aminotransferase 1, cytosolic) is localized to the cytoplasm where it forms a homodimer. ECA39 is expressed in the brain and kidney during embryogenesis and is overexpressed in c-Myc induced tumors. BCAT2 (branched-chain-amino-acid aminotransferase 2, mitochondrial), also known as placental protein 18 (PP18), is expressed as two isoforms produced by alternative splicing. The first isoform of BCAT2, designated BCAT2A, is expressed in the mitochondrion, while the second isoform, designated BCAT2B, is expressed in the cytoplasm. Ubiquitously expressed, BCAT2 is also thought to act as a transporter of branched chain α-keto acids. Function: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. Subunit: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. Subcellular Location: Cytoplasm and Mitochondrion. Tissue Specificity: Ubiquitous. Similarity: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. Database links: Entrez Gene: 587 Human Entrez Gene: 12036 Mouse Omim: 113530 Human SwissProt: O15382 Human SwissProt: O35855 Mouse Unigene: 512670 Human Unigene: 24210 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Ⅳ类磷酸吡哆醛依赖性氨基转移酶家族成员ECA39和BCAT2都是催化碱性支链氨基酸缬氨酸、亮氨酸和异亮氨酸分解代谢的第一反应的酶。ECA39，也称BCAT1（支链氨基酸转氨酶1，胞浆）定位在细胞质中，形成同型二聚体。ECA39在胚胎发育过程中在脑和肾中表达，并在c-myc诱导的肿瘤中过度表达。BCAT2（支链氨基酸转氨酶2，线粒体），也称为胎盘蛋白18（PP18），表达为两种由选择性剪接产生的异构体。BCAT2的第一个亚型，命名为BCAT2A，在线粒体中表达，而第二个亚型，命名为BCAT2B，在细胞质中表达。BCAT2的广泛表达也被认为是支链α-酮酸的转运蛋白。