FITC标记的脱氧尿苷三磷酸酶DUT抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的脱氧尿苷三磷酸酶DUT抗体
英文名称: Anti-DUT/FITC
抗体货号: HZ-6584R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/7/13 10:25:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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邮编:
200612
电话:
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上海·中国-上海
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产品详细描述

 Rabbit Anti-DUT/FITC Conjugated antibody

FITC标记的脱氧尿苷三***酸酶DUT抗体

 

英文名称 Anti-DUT/FITC
中文名称 FITC标记的脱氧尿苷三***酸酶DUT抗体
别    名 DUT-N; mitochondrial; Deoxyuridine 5' triphosphate nucleotidohydrolase, nuclear isofor; Deoxyuridine 5''-triphosphate nucleotidohydrolase; Deoxyuridine triphosphatase; dut; DUT_HUMAN; dUTP nucleotidohydrolase; dUTP pyrophosphatase; dUTPase; FLJ20622.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  染色质和核信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 19kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DUT (191-237aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Function:
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Subunit:
Homotrimer.

Subcellular Location:
Isoform 2: Nucleus. 
Isoform 3: Mitochondrion. 

Tissue Specificity:
Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level). 

Post-translational modifications:
Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated. 
The initiator methionine is cleaved in isoform 2. 

Similarity:
Belongs to the dUTPase family.

Database links:
UniProtKB/Swiss-Prot: P33316.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

这种酶参与核苷酸代谢:它产生倾倒,胸腺嘧***核苷酸的直接前体,它降低细胞内的DUTP浓度,因此尿嘧***不能结合到DNA中。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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