Rabbit Anti-RPL5/FITC Conjugated antibody
|别 名||60S ribosomal protein L5; MSTP030; Ribosomal protein L5; RL5; RL5_HUMAN; RP L5; RPL 5; RPL5; U21 RNA; U21RNA.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 细胞生物 神经生物学 肿瘤细胞生物标志物|
|交叉反应||Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||34kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human RPL5 (132-180aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.
Defects in RPL5 are the cause of Diamond-Blackfan anemia type 6 (DBA6) . DBA6 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
Belongs to the ribosomal protein L18P family.
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
Ribosomes，催化蛋白质合成的细胞器，由一个小的40S亚基和一个大的60S亚基组成。这些亚基由4种RNA和大约80种结构上不同的蛋白质组成。这个基因编码一个核糖体蛋白，它是60S亚基的一个组成部分。该蛋白属于L18P家族的核糖体蛋白。它位于细胞质中。该蛋白结合5S rRNA形成稳定的复合物，称为5S核糖核蛋白颗粒（RNP），这是将非核糖体相关的细胞质5S rRNA转运到核仁以组装成核糖体所必需的。该蛋白与酪蛋白激酶II的β亚基特异性相互作用。已经观察到该基因在结直肠癌中与相邻正常组织相比的可变表达，但未发现表达水平与疾病严重程度之间的相关性。该基因与位于其第五内含子的小核仁RNA基因U21共转录。对于编码核糖体蛋白的基因来说是典型的，这种基因的多个假基因通过基因组分散。