FITC标记的环指蛋白5抗体（E3泛素蛋白连接酶RNF5）
产品名称： FITC标记的环指蛋白5抗体（E3泛素蛋白连接酶RNF5）
英文名称： Anti-RING5/FITC
产品编号： HZ-6570R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-RING5/FITC Conjugated antibody
FITC标记的环指蛋白5抗体（E3泛素蛋白连接酶RNF5）
| 英文名称 | Anti-RING5/FITC |
| 中文名称 | FITC标记的环指蛋白5抗体（E3泛素蛋白连接酶RNF5） |
| 别 名 | E3 ubiquitin protein ligase RNF5; G16; HsRma1; NG2; OTTHUMP00000029107; Protein G16; Ring finger; protein 5; RING5; RMA1; RNF 5; RNF5_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RING5 (51-100aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. Function: Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'-linked polyubiquitination of TMEM173 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurrs in mitochondria after viral transfection and regulates antiviral responses. Subunit: Interacts with PXN. Interacts with Salmonella typhimurium sopA. Interacts with JKAMP. Interacts with TMEM173; the interaction of endogenous proteins is dependent on viral infection. Subcellular Location: Membrane; Multi-pass membrane protein. Mitochondrion membrane. Endoplasmic reticulum membrane. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles. Tissue Specificity: Widely expressed. Similarity: Contains 1 RING-type zinc finger. Database links: Entrez Gene: 6048 Human Entrez Gene: 54197 Mouse Entrez Gene: 407784 Rat Omim: 602677 Human SwissProt: Q99942 Human SwissProt: O35445 Mouse SwissProt: Q5M807 Rat Unigene: 718462 Human Unigene: 274542 Mouse Unigene: 136937 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
由该基因编码的蛋白质包含一个环指，这是一个已知的参与蛋白质-蛋白质相互作用的基序。这种蛋白是膜结合的泛素连接酶。它可以通过靶向帕西林泛素化来调节细胞的运动，改变PAXILN在细胞质和细胞黏附中的分布和定位。