FITC标记的抗细胞凋亡蛋白OLFM44抗体上海沪震实业有限公司

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产品名称: FITC标记的抗细胞凋亡蛋白OLFM44抗体
英文名称: Anti-OLFM4/FITC
抗体货号: HZ-6558R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/13 14:48:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-OLFM4/FITC Conjugated antibody

FITC标记的抗细胞凋亡蛋白OLFM44抗体

 

英文名称 Anti-OLFM4/FITC
中文名称 FITC标记的抗细胞凋亡蛋白OLFM44抗体
别    名 Antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; GC1; GW112; hGC 1; hGC-1; hOLfD; olfactomedin 4; Olfactomedin-4; OlfD; OLFM4; OLFM4_HUMAN; OLM4.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  肿瘤细胞生物标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 55kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human OLFM4
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein which contains one olfactomedin-like domain. OLFM4 is expressed during myeloid lineage development. It is strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. OLFM4 is highly expressed in pancreatic cancer tissues and shows an elevated expression level during the early S phase of the cell cycle. It is also expressed at high levels in stomach cancer and colon cancer tissues. Inhibition of ROS or the ERK pathway remarkably decreased G-CSF-induced OLFM4 expression. OLFM4 is an antiapoptotic factor that promotes tumor growth. OLFM4 promotes proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. OLFM4 also facilitates cell adhesion. Induction of OLFM4 in cancer cells was reported to have a novel antiapoptotic action via binding to the potent apoptosis inducer GRIM-19. The human OLFM4 is also thought to be a useful marker for early myeloid development.


Function:
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

Subunit:
Homomultimer; disulfide-linked. Interacts with NDUFA13. Interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin-A and wheat germ agglutinin) and cadherin.

Subcellular Location:
Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901).

Tissue Specificity:
Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.

Post-translational modifications:
N-glycosylated.

Similarity:
Contains 1 olfactomedin-like domain.

Database links:

Entrez Gene: 467367 Chimpanzee

Entrez Gene: 515082 Cow

Entrez Gene: 485470 Dog

Entrez Gene: 10562 Human

Entrez Gene: 380924 Mouse

Entrez Gene: 290409 Rat

Omim: 614061 Human

SwissProt: Q6UX06 Human

SwissProt: Q3UZZ4 Mouse

Unigene: 508113 Human

Unigene: 26456 Mouse

Unigene: 156265 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

嗅觉素-4,也称G-CSF刺激的克隆1蛋白,抗凋亡蛋白GW112和OLFM4,是一种分泌蛋白,含有一个嗅素样结构域。OLFM4在髓系发育过程中表达。它在前列腺、小肠和结肠中强烈表达,并在骨髓和胃中适度表达。OLFM4在胰腺癌组织中高表达,在细胞周期早期S期表达水平升高。它也在胃癌和结肠癌组织中高表达。ROS或ERK通路的抑制显著降低G-CSF诱导的OLFM4表达。OLFM4是一种促进肿瘤生长的抗凋亡因子。OLFM4促进胰腺癌细胞的增殖,有利于从S向G2/M期的转变。OLFM4也有利于细胞粘附。据报道,在癌细胞中诱导OLFM4通过结合强有力的凋亡诱导因子GRIM-19具有新的抗凋亡作用。人OLFM4也被认为是早期髓系发育的有用标志物。

 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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