FITC标记的抗细胞凋亡蛋白OLFM44抗体
产品名称: FITC标记的抗细胞凋亡蛋白OLFM44抗体
英文名称: Anti-OLFM4/FITC
产品编号: HZ-6558R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-OLFM4/FITC Conjugated antibody
FITC标记的抗细胞凋亡蛋白OLFM44抗体
英文名称 | Anti-OLFM4/FITC |
中文名称 | FITC标记的抗细胞凋亡蛋白OLFM44抗体 |
别 名 | Antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; GC1; GW112; hGC 1; hGC-1; hOLfD; olfactomedin 4; Olfactomedin-4; OlfD; OLFM4; OLFM4_HUMAN; OLM4. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 肿瘤细胞生物标志物 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 55kDa |
细胞定位 | 细胞膜 |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human OLFM4 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein which contains one olfactomedin-like domain. OLFM4 is expressed during myeloid lineage development. It is strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. OLFM4 is highly expressed in pancreatic cancer tissues and shows an elevated expression level during the early S phase of the cell cycle. It is also expressed at high levels in stomach cancer and colon cancer tissues. Inhibition of ROS or the ERK pathway remarkably decreased G-CSF-induced OLFM4 expression. OLFM4 is an antiapoptotic factor that promotes tumor growth. OLFM4 promotes proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. OLFM4 also facilitates cell adhesion. Induction of OLFM4 in cancer cells was reported to have a novel antiapoptotic action via binding to the potent apoptosis inducer GRIM-19. The human OLFM4 is also thought to be a useful marker for early myeloid development. Function: May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. Subunit: Homomultimer; disulfide-linked. Interacts with NDUFA13. Interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin-A and wheat germ agglutinin) and cadherin. Subcellular Location: Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). Tissue Specificity: Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. Post-translational modifications: N-glycosylated. Similarity: Contains 1 olfactomedin-like domain. Database links: Entrez Gene: 467367 Chimpanzee Entrez Gene: 515082 Cow Entrez Gene: 485470 Dog Entrez Gene: 10562 Human Entrez Gene: 380924 Mouse Entrez Gene: 290409 Rat Omim: 614061 Human SwissProt: Q6UX06 Human SwissProt: Q3UZZ4 Mouse Unigene: 508113 Human Unigene: 26456 Mouse Unigene: 156265 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
嗅觉素-4,也称G-CSF刺激的克隆1蛋白,抗凋亡蛋白GW112和OLFM4,是一种分泌蛋白,含有一个嗅素样结构域。OLFM4在髓系发育过程中表达。它在前列腺、小肠和结肠中强烈表达,并在骨髓和胃中适度表达。OLFM4在胰腺癌组织中高表达,在细胞周期早期S期表达水平升高。它也在胃癌和结肠癌组织中高表达。ROS或ERK通路的抑制显著降低G-CSF诱导的OLFM4表达。OLFM4是一种促进肿瘤生长的抗凋亡因子。OLFM4促进胰腺癌细胞的增殖,有利于从S向G2/M期的转变。OLFM4也有利于细胞粘附。据报道,在癌细胞中诱导OLFM4通过结合强有力的凋亡诱导因子GRIM-19具有新的抗凋亡作用。人OLFM4也被认为是早期髓系发育的有用标志物。