FITC标记的2号染色体开放阅读框6抗体上海沪震实业有限公司

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产品名称: FITC标记的2号染色体开放阅读框6抗体
英文名称: Anti-C2orf6/MOBK1B/FITC
抗体货号: HZ-6549R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/7/13 10:58:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-C2orf6/MOBK1B/FITC Conjugated antibody

FITC标记的2号染色体开放阅读框6抗体

 

英文名称 Anti-C2orf6/MOBK1B/FITC
中文名称 FITC标记的2号染色体开放阅读框6抗体
别    名 C2orf6; Chromosome 2 open reading frame 6; MATS1; MOB1; Mob1 alpha; Mob1 homolog 1B; MOB1 Mps One Binder kinase activator like 1B; Mob1A; MOB4B; Mob4B protein; MOBKL1B; MOBK1B; MOL1B_HUMAN; Mps one binder kinase activator like 1B; Mps one binder kinase activator-like 1B; Protein Mob4B.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  信号转导  干细胞  激酶和***酸酶  肿瘤细胞生物标志物  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MOBK1B/C2orf6
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.



Function:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Subunit:
Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.

Tissue Specificity:
Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.

Post-translational modifications:
Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. 

Similarity:
Belongs to the MOB1/phocein family.

Database links:

Entrez Gene: 55233 Human

Entrez Gene: 232157 Mouse

Entrez Gene: 100366014 Rat

Entrez Gene: 297387 Rat

Omim: 609281 Human

SwissProt: Q9H8S9 Human

SwissProt: Q921Y0 Mouse

SwissProt: Q3T1J9 Rat

Unigene: 29500 Mouse

Unigene: 74475 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

LIPS1/2在HIPO信号通路中的激活剂,通过限制增殖和促进细胞凋亡在器官大小控制和肿瘤抑制中起关键作用。该通路的核心由激酶级联组成,其中MST1/MST2在其调控蛋白Sav1的复合物中***酸化,并在其调控蛋白MOB1中激活LATS1/2,进而***酸化和灭活YAP1癌蛋白和WWTR1/TAZ。LAPS1/2对YAP1的***酸化抑制其转运到细胞核中,以调节细胞增殖、细胞死亡和细胞迁移的重要细胞基因。刺激STK38和STK38 L的激酶活性。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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