FITC标记的候选肿瘤抑制基因MARVELD1抗体
产品名称： FITC标记的候选肿瘤抑制基因MARVELD1抗体
英文名称： Anti-MARVELD1/FITC
产品编号： HZ-6548R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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- 邮编 : 200612
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Rabbit Anti-MARVELD1/FITC Conjugated antibody
FITC标记的候选肿瘤抑制基因MARVELD1抗体
| 英文名称 | Anti-MARVELD1/FITC |
| 中文名称 | FITC标记的候选肿瘤抑制基因MARVELD1抗体 |
| 别 名 | GB14; MARVD1; MARVEL (membrane-associating) domain containing 1; MARVEL domain containing protein 1; MRVLDC1; Putative MARVEL domain containing protein 1; MALD1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 肿瘤细胞生物标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MARVELD1 (31-80aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity. Function: Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration Subcellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization. Tissue Specificity: Widely expressed in normal tissues. Down-regulated in multiple primary tumors. Similarity: Contains 1 MARVEL domain. Database links: UniProtKB/Swiss-Prot: Q9BSK0.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
MARVELD1，（MARVEL域包含1），是MARVEL（MACLE和相关蛋白的囊泡运输和膜连接）结构域的一种蛋白质。它是一种在正常人体组织中广泛表达的核定位蛋白。虽然据报道，在结肠癌中过表达，MARVELD1蛋白水平通常在几个原发肿瘤，包括卵巢，乳腺，肾，膀胱和肝脏普遍较低。MARVELD1在肿瘤中的低表达被认为是由于MARVELD1启动子甲基化状态的提高，随着5-AZA-2′-脱氧胞苷恢复MARVELD1的表达，MARVELD1的表达可能有助于肿瘤的发生。