Rabbit Anti-LDOC1/FITC Conjugated antibody
|别 名||BCUR1; Breast cancer up regulated 1; Breast cancer upregulated 1; Gm366; Leucine zipper down regulated in cancer 1; Leucine zipper protein down regulated in cancer cells; Leucine zipper protein down regulated in cancer cells; Mar7; Mart7; Protein LDOC1; RGD1565644; LDOC1_HUMAN .|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||肿瘤 染色质和核信号 信号转导 转录调节因子 肿瘤细胞生物标志物 表观遗传学|
|交叉反应||Human, Dog, Pig, Horse, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||17kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human LDOC1|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008].
May have an important role in the development and/or progression of some cancers.
Ubiquitously expressed with high levels in brain and thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.
Belongs to the LDOC1 family.
Entrez Gene: 23641 Human
Omim: 300402 Human
SwissProt: O95751 Human
Unigene: 45231 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
由该基因编码的蛋白质包含亮氨酸拉链状基序和富含脯氨酸的区域，其与SH3结合结构域具有显著的相似性。蛋白质定位于细胞核，在某些癌细胞系中被下调。它被认为是调节核转录因子-κB（NF-kappaB）介导的转录应答。该基因已被提出作为肿瘤抑制基因，其蛋白产物可能在一些癌症的发展和/或进展中具有重要的作用。[ RefSeq，JUL 2008 ]提供。