FITC标记的DNA结合抑制因子1抗体
产品名称： FITC标记的DNA结合抑制因子1抗体
英文名称： Anti-ID1/FITC
产品编号： HZ-6541R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-ID1/FITC Conjugated antibody
FITC标记的DNA结合抑制因子1抗体
| 英文名称 | Anti-ID1/FITC |
| 中文名称 | FITC标记的DNA结合抑制因子1抗体 |
| 别 名 | bHLHb24; Class B basic helix-loop-helix protein 24; DNA binding protein inhibitor ID 1; DNA binding protein inhibitor ID1; DNA-binding protein inhibitor ID-1; Dominant negative helix loop helix protein; ID 1; ID; ID-1; ID1_HUMAN; Inhibitor of Differentiation 1; Inhibitor of DNA binding 1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 染色质和核信号 信号转导 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ID1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ID proteins contain a helix-loop-helix (HLH) motif and regulate tissue-specific transcription within several cell lineages. They do not bind DNA directly, but inhibit lineage commitment by binding basic helix-loop-helix (bHLH) transcription factors through their HLH motif. ID proteins contribute to cell growth, senescence, differentiation and angiogenesis. Id1 mRNA is highly expressed in heart, lung and kidney and has lower expression in brain and liver. Two transcript variants encoding different isoforms have been found for this gene. Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. Subunit: Heterodimer with other HLH proteins. Interacts with COPS5 (By similarity). Subcellular Location: Cytoplasm (By similarity). Nucleus. Similarity: Contains 1 bHLH (basic helix-loop-helix) domain. Database links: Entrez Gene: 3397 Human Entrez Gene: 15901 Mouse Entrez Gene: 25261 Rat Omim: 600349 Human SwissProt: P41134 Human SwissProt: P20067 Mouse SwissProt: P41135 Rat Unigene: 504609 Human Unigene: 444 Mouse Unigene: 2113 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ID蛋白包含螺旋环螺旋（HLH）基序，并调节多个细胞谱系中的组织特异性转录。它们不直接结合DNA，而是通过碱基螺旋环螺旋（BHLH）转录因子通过它们的HLH基序来抑制谱系承诺。Id蛋白有助于细胞的生长、衰老、分化和血管生成。ID1 mRNA在心脏、肺和肾脏中高表达，在脑和肝脏中表达较低。发现了两个编码不同亚型的转录变体。