Rabbit Anti-DDX4/FITC Conjugated antibody
|别 名||DDX 4; DEAD (Asp Glu Ala Asp) box polypeptide 4; Dead box protein 4; Dead-box protein 4; MGC111074; MVH; Probable ATP dependent RNA helicase DDX4; VASA; VASA homolog; DDX4_HUMAN.|
Zoological Science (2014)
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|交叉反应||Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||80kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human DDX4/MVH|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
May play a role in germ cell development. May play a role in sperm motility.
Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. N-terminus interacts with RANBP9. Interacts with PIWIL2 and MAEL.
Cytoplasm. Cytoplasm, perinuclear region.
Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
Belongs to the DEAD box helicase family. DDX4/VASA subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Entrez Gene: 54514 Human
Entrez Gene: 13206 Mouse
Entrez Gene: 310090 Rat
Omim: 605281 Human
SwissProt: Q5W5U4 Cow
SwissProt: Q9NQI0 Human
SwissProt: Q61496 Mouse
SwissProt: Q6GWX0 Pig
SwissProt: Q64060 Rat
Unigene: 223581 Human
Unigene: 12818 Mouse
Unigene: 198577 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
摘要：死盒蛋白，其特征在于保守的主题ASP Glu ALA-ASP（死），是公认的RNA解旋酶。它们涉及许多细胞过程，涉及RNA二级结构的改变，如翻译起始、核和线粒体剪接、核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与胚胎发生、精子发生和细胞生长和分裂。该基因编码一个死盒蛋白，这是Drosophila和其他一些物种的VasA蛋白的同源物。该基因在生殖细胞谱系中特异表达，在生殖细胞发育中发挥作用。该基因已发现编码不同亚型的多个转录变体。[由RefSeq提供]。