FITC标记的金属应答元件结合转录因子-1抗体
产品名称: FITC标记的金属应答元件结合转录因子-1抗体
英文名称: Anti-MTF-1/FITC
产品编号: HZ-3601R-FITC
产品价格: null
产品产地: 中国/上海
品牌商标: HZbscience
更新时间: 2023-08-17T10:24:20
使用范围: IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-MTF-1/FITC Conjugated antibody
FITC标记的金属应答元件结合转录因子-1抗体
英文名称 | Anti-MTF-1/FITC |
中文名称 | FITC标记的金属应答元件结合转录因子-1抗体 |
别 名 | Metal regulatory transcription factor 1; Metal response element binding transcription factor 1; MRE binding transcription factor; Transcription factor MTF1; MTF1_HUMAN. |
规格价格 | 100ul/2980元 购买 大包装/询价 |
说 明 书 | 100ul |
研究领域 | 肿瘤 细胞生物 免疫学 染色质和核信号 转录调节因子 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, |
产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
分 子 量 | 81kDa |
性 状 | Lyophilized or Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human MTF-1 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
产品介绍 | background: The zinc finger transcription factor MTF-1 (metal-responsive transcription factor-1) is conserved from insects to vertebrates. The major role of MTF-1 in both organisms is to control the transcription of genes involved in the homeostasis and detoxification of heavy metal ions such as Cu2+, Zn2+ and Cd2+. In mammals, MTF-1 serves at least two additional roles. First, targeted disruption of the MTF-1 gene results in death at embryonic day 14 due to liver degeneration, revealing a stage-specific developmental role. Second, under hypoxic-anoxic stress, MTF-1 helps to activate the transcription of the gene placental growth factor (PIGF), an angiogenic protein. Function: Activates the metallothionein I promoter. Binds to the metal responsive element (MRE). Subcellular Location: Nucleus. Similarity: Contains 6 C2H2-type zinc fingers. Database links: Entrez Gene: 4520 Human Omim: 600172 Human SwissProt: Q14872 Human Unigene: 471991 Human Unigene: 591505 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 锌感应蛋白金属反应转录因子-1 |
锌指转录因子MTF-1(金属应答转录因子-1)是从昆虫到脊椎动物的保守。MTF-1在两种生物体中的主要作用是控制参与重金属离子的稳态和解毒的基因的转录,如Cu2+、Zn2+和Cd2+。在哺乳动物中,MTF-1至少起到另外两种作用。首先,靶向破坏MTF-1基因导致在胚胎第14天由于肝脏变性导致死亡,揭示了阶段特异性发育作用。其次,在缺氧缺氧胁迫下,MTF-1有助于激活胎盘生长因子(PIGF)的转录,这是一种血管生成蛋白。