FITC标记的胱抑素C/半胱氨酸蛋白酶抑制剂C抗体上海沪震实业有限公司

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产品名称: FITC标记的胱抑素C/半胱氨酸蛋白酶抑制剂C抗体
英文名称: Anti-Cystatin C/FITC
抗体货号: HZ-3595R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 9:47:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Cystatin C/FITC Conjugated antibody 

FITC标记的胱抑素C/半胱氨酸蛋白酶抑制剂C抗体

 

英文名称 Anti-Cystatin C/FITC
中文名称 FITC标记的胱抑素C/半胱氨酸蛋白酶抑制剂C抗体
别    名 Cystatin 3; Cystatin-3; CST 3;CST3; CST-3; Cystatin C; AD 8; AD8; Amyloid angiopathy and cerebral hemorrhage; Cst 3; Cst3; CST3 protein; Cystatin 3; Cystatin3; CystatinC; Gamma trace; HCCAA; Neuroendocrine basic polypeptide; Post gamma globulin; ARMD11; MGC117328; CYSC.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  心血管  细胞生物  免疫学  发育生物学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse, Rat, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Cystatin 3
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeq].

Function:
As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

Subunit:
Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.

Subcellular Location:
Secreted.

DISEASE:
Defects in CST3 are the cause of amyloidosis type 6 (AMYL6) [MIM:105150]; also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low. 

Similarity:
Belongs to the cystatin family.

Database links:

Entrez Gene: 1471 Human

Entrez Gene: 13010 Mouse

Entrez Gene: 25307 Rat

Omim: 604312 Human

SwissProt: P01034 Human

SwissProt: P21460 Mouse

SwissProt: P14841 Rat

Unigene: 304682 Human

Unigene: 4263 Mouse

Unigene: 106351 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

胱抑素C( cystatin c)是一种半胱氨酸蛋白酶抑制剂,也被称为γ-微量蛋白及γ-后球蛋白,广泛存在于各种组织的有核细胞和体液中,是一种低分子量、碱性非糖化蛋白质,分子量为13.3KD,由122个氨基酸残基组成,可由机体所有有核细胞产生,产生率恒定。循环中的胱抑素c仅经肾小球滤过而被清除,是一种反映肾小球滤过率变化的内源性标志物,并在近曲小管重吸收,但重吸收后被完全代谢分解,不返回血液,因此,其血中浓度由肾小球滤过决定,而不依赖任何外来因素,如性别、年龄、饮食的影响,是一种反映肾小球滤过率变化的理想同源性标志物
   

半胱氨酸蛋白酶抑制剂超家族包含含有多种半胱氨酸蛋白酶抑制剂序列的蛋白质。有些成员是活性半胱氨酸蛋白酶抑制剂,而另一些则失去或可能从未获得这种抑制活性。超家族中有三个抑制性家族,包括1型半胱氨酸蛋白酶抑制剂(Syfin)、2型半胱氨酸蛋白酶抑制剂和激肽原。2型半胱氨酸蛋白酶抑制剂蛋白是一类半胱氨酸蛋白酶抑制剂,存在于多种人类流体和分泌物中,在那里它们似乎提供了保护功能。20号染色体上的半胱氨酸蛋白酶抑制剂基因座包含2型半胱氨酸蛋白酶抑制剂基因和假基因的大部分。该基因位于半胱氨酸蛋白酶抑制剂位点,编码最丰富的半胱氨酸蛋白酶胞外抑制剂,其在生物流体中高浓度存在,并几乎在身体的所有器官中表达。该基因的突变与淀粉样血管病有关。在动脉粥样硬化和动脉瘤性主动脉病变中,这种蛋白在血管壁平滑肌细胞中的表达被严重降低,在血管疾病中发挥其作用。[由RefSeq提供]。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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