FITC标记的丝裂原活化蛋白激酶激酶8抗体上海沪震实业有限公司

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产品名称: FITC标记的丝裂原活化蛋白激酶激酶8抗体
英文名称: Anti-MAP3K8/FITC
抗体货号: HZ-3591R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: 
更新时间: 2018/8/27 14:39:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-MAP3K8/FITC Conjugated antibody

FITC标记的丝裂原活化蛋白激酶激酶8抗体

 

英文名称 Anti-MAP3K8/FITC
中文名称 FITC标记的丝裂原活化蛋白激酶激酶8抗体
别    名 c COT; Cancer Osaka thyroid oncogene; Cancer Osaka thyroid oncogene; CCOT; COT; COT proto oncogene serine/threonine protein kinase; EST; ESTF; Ewing sarcoma transformant; FLJ10486; M3K8_HUMAN; MAP3K 8; MAP3K8; Mitogen activated protein kinase kinase kinase 8; Mitogen-activated protein kinase kinase kinase 8; Proto oncogene cCot; Proto-oncogene c-Cot; Serine/threonine protein kinase cot; Serine/threonine-protein kinase cot; TPL 2; TPL-2; TPL2; Tumor progression locus 2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  细胞生物  免疫学  信号转导  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, 
产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MAP3K8/TPL2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Function:
Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein. 

Subunit:
Forms a ternary complex with NFKB1 and TNIP2.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in several normal tissues and human tumor-derived cell lines.

Post-translational modifications:
Autophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues. 

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 1326 Human

Entrez Gene: 26410 Mouse

Entrez Gene: 116596 Rat

Omim: 191195 Human

SwissProt: P41279 Human

SwissProt: Q07174 Mouse

SwissProt: Q63562 Rat

Unigene: 432453 Human

Unigene: 3275 Mouse

Unigene: 9939 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

该基因是编码丝氨酸/苏氨酸蛋白激酶家族成员的致癌基因。编码的蛋白质定位于细胞质,并能激活MAP激酶和JNK激酶通路。该蛋白可激活IkApAb激酶,从而诱导NF-κB的核生成。在T淋巴细胞活化过程中,还发现该蛋白促进TNF-α和IL-2的产生。该基因还可以利用下游的框翻译起始密码子,从而产生包含较短的N-末端的异构体。较短的异构体已被证明显示较弱的转化活性。交替剪接导致编码同一蛋白质的多个转录变体。[ RefSeq,SEP 2011提供]

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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