FITC标记的磷酸化CREB转录共激
产品名称： FITC标记的磷酸化CREB转录共激
英文名称： Anti-Phospho-Torc1 (Ser151)/FITC
产品编号： HZ--3453R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Phospho-Torc1 (Ser151)/FITC Conjugated antibody
FITC标记的磷酸化CREB转录共激
| 英文名称 | Anti-Phospho-Torc1 (Ser151)/FITC |
| 中文名称 | FITC标记的磷酸化CREB转录共激 |
| 别 名 | Phospho-Torc1/Crtc1 (Ser151); Phospho-Torc1(Ser151); P-Torc1 (Ser151); Crtc1 (Ser151); Crtc1 (Phospho S151); CREB regulated transcription coactivator 1; CRTC1; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated protein 1; also known as MucoEpidermoid Carcinoma Translocated 1; TORC1; Transducer of CREB protein 1; Transducer of regulated cAMP response element binding protein 1; WAMTP1; MECT1; TORC1; TORC-1; WAMTP1; CRTC1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 免疫学 神经生物学 信号转导 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 70kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Torc1 around the phosphorylation site of Ser151 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Subunit: Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax. Subcellular Location: Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. Tissue Specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Post-translational modifications: Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR DISEASE: Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas. Similarity: Belongs to the TORC family. Database links: Entrez Gene: 23373?/span>Human Entrez Gene: 382056?/span>Mouse Entrez Gene: 684527?/span>Rat Omim: 607536?/span>Human SwissProt: Q6UUV9?/span>Human SwissProt: Q68ED7?/span>Mouse SwissProt: Q157S1?/span>Rat Unigene: 371096?/span>Human Unigene: 428214?/span>Human Unigene: 227767?/span>Mouse Unigene: 208248?/span>Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
通过共同的和变异的cAMP应答元件（CRE）位点激活转录。MeCT1似乎不调节CREB1 DNA结合活性，但增强CREB1与TaF4/TaFIi-130的相互作用。MTEC1与MAML2（Mist操纵蛋白样蛋白2）转移，产生融合癌基因：T（11；19）（q21；p13）。这种易位发生在粘液表皮样癌、良性疣状肿瘤和透明细胞汗腺瘤。新的融合产物会破坏Notch信号通路。融合蛋白由MeCT1的N-末端连接到MAML2的C末端。在少量粘液表皮样癌中检测到MMEL2的N-末端连接到MCET1的C末端的相互融合蛋白。多个异构体已被报道的MTEC1蛋白。