FITC标记的环腺苷酸应答元件结合蛋白转录共激活因子TORC1抗体上海沪震实业有限公司

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产品名称: FITC标记的环腺苷酸应答元件结合蛋白转录共激活因子TORC1抗体
英文名称: Anti-TORC1/CRTC1/FITC
抗体货号: HZ-3588R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: IF=1:50-200
更新时间: 2018/8/9 10:02:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-TORC1/CRTC1/FITC Conjugated antibody 

FITC标记的环腺苷酸应答元件结合蛋白转录共激活因子TORC1抗体

 

英文名称 Anti-TORC1/CRTC1/FITC
中文名称 FITC标记的环腺苷酸应答元件结合蛋白转录共激活因子TORC1抗体
别    名 CREB regulated transcription coactivator 1; CRTC1; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated protein 1; also known as MucoEpidermoid Carcinoma Translocated 1; TORC1; Transducer of CREB protein 1; Transducer of regulated cAMP response element binding protein 1; WAMTP1; MECT1; TORC1; TORC-1; WAMTP1; CRTC1_HUMAN.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  免疫学  信号转导  细胞凋亡  转录调节因子  激酶和***酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, 
产品应用 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TORC1
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

Function:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity).

Subunit:
Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.

Subcellular Location:
Cytoplasm. Nucleus. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels.

Tissue Specificity:
Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

Post-translational modifications:
Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR

DISEASE:
Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

Similarity:
Belongs to the TORC family.

Database links:

Entrez Gene: 23373 Human

Entrez Gene: 382056 Mouse

Entrez Gene: 684527 Rat

Omim: 607536 Human

SwissProt: Q6UUV9 Human

SwissProt: Q68ED7 Mouse

SwissProt: Q157S1 Rat

Unigene: 371096 Human

Unigene: 428214 Human

Unigene: 227767 Mouse

Unigene: 208248 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   
   

通过共同的和变异的cAMP应答元件(CRE)位点激活转录。MeCT1似乎不调节CREB1 DNA结合活性,但增强CREB1与TaF4/TaFIi-130的相互作用。MTEC1与MAML2(Mist操纵蛋白样蛋白2)转移,产生融合癌基因:T(11;19)(q21;p13)。这种易位发生在粘液表皮样癌、良性疣状肿瘤和透明细胞汗腺瘤。新的融合产物会破坏Notch信号通路。融合蛋白由MeCT1的N-末端连接到MAML2的C末端。在少量粘液表皮样癌中检测到MMEL2的N-末端连接到MCET1的C末端的相互融合蛋白。多个异构体已被报道的MTEC1蛋白。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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